HLA class I molecules present endogenously processed peptide ligands for surveillance by the T-cell receptor. This potentially immunogenic surface of HLA and peptide is a consequence of the polymorphism found within the HLA molecule and its preference for ligand binding together with peptide conformation within the binding groove. To investigate the relation between the polymorphic differences between some closely related HLA alleles and their effect on peptide preference, transfectants were established, each containing one of four allelic variants of HLA-A*30. Peptides from all four transfectants were eluted, and both individual ligands and peptide pools were sequenced. The data shows two distinct peptide motifs which distinguish A*3001 fr...
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T ly...
HLA genes are essential immune genes coding for cell-surface proteins that are responsible in antige...
CD8(+) T cells identify and kill infected cells through the specific recognition of short viral anti...
HLA class I molecules present endogenously processed peptide ligands for surveillance by the T-cell ...
AbstractBackground: Polymorphism among class I molecules of the major histocompatibility complex (MH...
The consensus motifs of HLA-Cw3, -Cw4, -Cw6, and -Cw7 ligands were determined by pool sequencing. To...
Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune ...
Herein we describe the establishment of assays to measure peptide binding to purified HLA-B*0701, -B...
The peptides presented by major histocompatibility complex class I molecules adhere to strict rules ...
<div><p>HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage...
Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all p...
Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display peptides on a...
Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display peptides on a...
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and code for p...
HLA class I molecule (HLA-A, B, C gene products) consists of 2 polypeptide chains: a polymorphic hea...
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T ly...
HLA genes are essential immune genes coding for cell-surface proteins that are responsible in antige...
CD8(+) T cells identify and kill infected cells through the specific recognition of short viral anti...
HLA class I molecules present endogenously processed peptide ligands for surveillance by the T-cell ...
AbstractBackground: Polymorphism among class I molecules of the major histocompatibility complex (MH...
The consensus motifs of HLA-Cw3, -Cw4, -Cw6, and -Cw7 ligands were determined by pool sequencing. To...
Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune ...
Herein we describe the establishment of assays to measure peptide binding to purified HLA-B*0701, -B...
The peptides presented by major histocompatibility complex class I molecules adhere to strict rules ...
<div><p>HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage...
Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all p...
Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display peptides on a...
Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display peptides on a...
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and code for p...
HLA class I molecule (HLA-A, B, C gene products) consists of 2 polypeptide chains: a polymorphic hea...
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T ly...
HLA genes are essential immune genes coding for cell-surface proteins that are responsible in antige...
CD8(+) T cells identify and kill infected cells through the specific recognition of short viral anti...