Evaluation Of A Novel Composite Based On Functionalized Multi-walled Carbon Nanotube And Iron Phthalocyanine For Electroanalytical Determination Of Isoniazid

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)A novel platform for electroanalysis of isoniazid based on graphene-functionalized multi-walled carbon nanotube as support for iron phthalocyanine (FePc/f-MWCNT) has been developed. The FePc/f-MWCNT composite has been dropped on glassy carbon forming FePc/f-MWCNT/GC electrode, which is sensible for isoniazid, decreasing substantially its oxidation potential to +200 mV vs Ag/AgCl. Electrochemical and electroanalytical properties of the FePc/f-MWCNT/GC-modified electrode were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electrochemical microscopy, and amperometry. The sensor presents better performance in 0.1 mol L-1 phosphate buffer at pH 7.4. Under optimized conditions, a linear response range from 5 to 476 mu mol L-1 was obtained with a limit of detection and sensitivity of 0.56 mu mol L-1 and 0.023 mu A L mu mol(-1), respectively. The relative standard deviation for 10 determinations of 100 mu mol L-1 isoniazid was 2.5%. The sensor was successfully applied for isoniazid selective determination in simulated body fluids.21410891099FAPEMA [00738/2014, BM-01363/15, 00753/14]CNPq [305865/2013-7, 401689/2015-8, 305680/2015-3]FAPESP [2014/02163-7]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP