Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of TP53, MDM2, BAX, and BCL2 expression. We analyzed herein sex differences in outcomes of CM patients associated with TP53 c.215G>C, MDM2 c.309T>G, BAX c.-248G>A, and BCL2 c.-717C>A polymorphisms. DNA from 121 men and 116 women patients was analyzed by polymerase chain reaction and enzymatic digestion assays. At 60 months of follow-up, shorter progression-free survival (PFS) was seen in males with MDM2 GG + BCL2 AA (20.0 vs. 62.6%, P = 0.0008) genotype. Men carriers of the genotype had poor PFS (HR 3.78, 95% CI 1.30-11.0) than others. For women, shorter P...
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness...
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness...
Male gender is independently and significantly associated with poor prognosis in melanoma of all cli...
Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this ...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Background: The P53 Arg72Pro, MDM2 c.+3...
Melanoma accounts for the majority of deaths from skin cancer. Women tend to be diagnosed at a young...
This study aimed to evaluate whether XPC A2920C, XPF T30028C, TP53 Arg72Pro, and GSTP1 Ile105Val pol...
Melanoma accounts for the majority of deaths from skin cancer. Women tend to be diagnosed at a young...
Os genes P53 e BAX (pró-apoptóticos) e MDM2 e BCL2 (antiapoptóticos) atuam na morte de células epite...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
A functional single nucleotide polymorphism (SNP) 309 T/G within mouse double minute 2 (MDM2) gene h...
MDM2-SNP309 (rs2279744), a common genetic modifier of cancer incidence in Li-Fraumeni syndrome, modi...
A female advantage in melanoma incidence and outcome has been consistently observed but remains unex...
To identify genetic variants involved in prognosis of cutaneous melanoma (CM), we investigated assoc...
Background: Survival from melanoma is strongly related to patient sex, with females having a surviva...
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness...
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness...
Male gender is independently and significantly associated with poor prognosis in melanoma of all cli...
Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this ...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Background: The P53 Arg72Pro, MDM2 c.+3...
Melanoma accounts for the majority of deaths from skin cancer. Women tend to be diagnosed at a young...
This study aimed to evaluate whether XPC A2920C, XPF T30028C, TP53 Arg72Pro, and GSTP1 Ile105Val pol...
Melanoma accounts for the majority of deaths from skin cancer. Women tend to be diagnosed at a young...
Os genes P53 e BAX (pró-apoptóticos) e MDM2 e BCL2 (antiapoptóticos) atuam na morte de células epite...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
A functional single nucleotide polymorphism (SNP) 309 T/G within mouse double minute 2 (MDM2) gene h...
MDM2-SNP309 (rs2279744), a common genetic modifier of cancer incidence in Li-Fraumeni syndrome, modi...
A female advantage in melanoma incidence and outcome has been consistently observed but remains unex...
To identify genetic variants involved in prognosis of cutaneous melanoma (CM), we investigated assoc...
Background: Survival from melanoma is strongly related to patient sex, with females having a surviva...
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness...
Prognosis of primary melanoma is presently based on morphological parameters, mainly tumor thickness...
Male gender is independently and significantly associated with poor prognosis in melanoma of all cli...