Effect of total flavone of epimedium on the mice model of perimenopausal syndrome

To investigate the effect of total flavone of Epimedium (TFE) on the model of perimenopausal syndrome (PMS) in mice, and to lay the foundation for the development of the drug which is effective for the treatment of PMS. The castration method making PMS animal model, observe the high, medium and small dose of TFE on PMS model mice Viscera index, serum sex hormones and organ histomorphology. Compared with the blank group, the uterus index, serum E2 levels of model group decreased significantly (P < 0.01), LH and FSH levels were significantly increased (P < 0.01), endometrial thickness of mice in model group, muscle layer thickness, thickness of thymic cortex and cortical lymphocytes number, volume of splenic nodule were significantly reduced (P < 0.01) which explained the model was successful. Compared with the model group, the drug group of TFE could different degree increase thymus index, uterus index, serum E2 level; reduce levels of LH and FSH; endometrium, the thickness of thymic cortex increased, increased volume of splenic nodule, and increase the number of lymphocytes. Conclusion: TFE has a significant effect on the treatment of PMS