Add to ORKGModulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electroconvulsive shock (ECS). Altered 5-HT receptor expression may play a role in this process. We have measured the mRNAs encoding 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors, and the 5-HT transporter, in rat brain after single ECS, repeated ECS, and 3 weeks after repeated ECS. Hippocampal 5-HT1A receptor mRNA was decreased in CA4 and increased in dentate gyrus by single or repeated ECS, with parallel alterations in [3H]8-OH-DPAT binding site densities. Repeated ECS increased cortical [3H]ketanserin binding and 5-HT2A receptor mRNA. The other mRNAs were unchanged. The results show that ECS has subtype specific, anatomically discrete, and temporally...
This study assessed the in vivo effects of various serotonin (5-HT) receptor modulators on 5-HT neur...
Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has been asso...
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT i...
Modulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electro...
We investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, o...
Recent studies have suggested that the substance P (tachykinin NK(1)) receptor may be a pharmacologi...
Glutamate and its receptors are involved in the pathophysiology of mood disorders and have recently ...
The neural basis underlying the cognitive side effects of ECT is unknown. Recent studies suggest tha...
In our previous positron emission tomography (PET) study, we demonstrated that ECT decreased dopamin...
ERK5-MEF2C has been implicated in many aspects of neuronal survival and neuroprotection. Neurotrophi...
Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippoc...
The inositol lipid system (polyphosphoinositides and inositol phosphates) represents an important co...
Rats were submitted to single or repeated (7 days, one session for each day) sessions of electroconv...
Much evidence suggests that variation in expression of the 5-hydroxytryptamine (5-HT) transporter (5...
Electroconvulsive therapy (ECT) effectively treats depression by administration of repeated seizure-...
This study assessed the in vivo effects of various serotonin (5-HT) receptor modulators on 5-HT neur...
Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has been asso...
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT i...
Modulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electro...
We investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, o...
Recent studies have suggested that the substance P (tachykinin NK(1)) receptor may be a pharmacologi...
Glutamate and its receptors are involved in the pathophysiology of mood disorders and have recently ...
The neural basis underlying the cognitive side effects of ECT is unknown. Recent studies suggest tha...
In our previous positron emission tomography (PET) study, we demonstrated that ECT decreased dopamin...
ERK5-MEF2C has been implicated in many aspects of neuronal survival and neuroprotection. Neurotrophi...
Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippoc...
The inositol lipid system (polyphosphoinositides and inositol phosphates) represents an important co...
Rats were submitted to single or repeated (7 days, one session for each day) sessions of electroconv...
Much evidence suggests that variation in expression of the 5-hydroxytryptamine (5-HT) transporter (5...
Electroconvulsive therapy (ECT) effectively treats depression by administration of repeated seizure-...
This study assessed the in vivo effects of various serotonin (5-HT) receptor modulators on 5-HT neur...
Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has been asso...
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT i...