Functionalized Silica Nanoparticles As An Alternative Platform For Targeted Drug-delivery Of Water Insoluble Drugs

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The selective action of drugs in tumor cells is a major problem in cancer therapy. Most chemotherapy drugs act nonspecifically and damage both cancer and healthy cells causing various side effects. In this study, the preparation of a selective drug delivery system, which is able to act as a carrier for hydrophobic and anticancer drugs is reported. Amino-functionalized silica nanoparticles loaded with curcumin were successfully synthesized via sol-gel approach and duly characterized. Thereafter, the targeting ligand, folate, was covalently attached to amino groups of nanoparticle surface through amide bond formation. The cytotoxic effect of nanoparticles on prostate cancer cells line was evaluated and compared to normal cells line (prostate epithelial cell). Cytotoxicity experiments demonstrated that folate-functionalized nanoparticles were significantly cytotoxic to tumor cells, whereas normal cells were much less affected by the presence of these structures. © 2016 American Chemical Society.32321732252014/22322-2, FAPESP, São Paulo Research FoundationFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP