Fat-specific dicer deficiency accelerates aging and mitigates several effects of dietary restriction In mice
- Reis, Felipe C. G.
- Branquinho, Jéssica L. O.
- Brandão, Bruna B.
- Guerra, Beatriz A.
- Silva, Ismael D.
- Frontini, Andrea
- Thomou, Thomas
- Sartini, Loris
- Cinti, Saverio
- Kahn, C. Ronald
- Festuccia, William T.
- Kowaltowski, Alicia J.
DOIAbstract
Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes ‐ mainly Dicer ‐ that occurs with aging in mouse white8612011222FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNQP - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR2010/52557-02015/01316-72011/24109-6SEM INFORMAÇÃOSEM INFORMAÇÃOWe thank Emanuel B. Cabral, Ivan H. Cordeiro, Grazielle C. R. da Silva and Mariana C. dos Santos, of the Federal University of Sao Paulo, for technical suppor
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