A Field Guide To Current Advances In Paediatric Movement Disorders

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Purpose of review Recent advances in neurogenetics, neuroimmunology and nonpharmacological treatments have reshaped the field of paediatric movement disorders. In this review, we put recent findings into context providing a framework to enable navigation of the expanding literature in this field. Recent findings Anti-NMDA receptor encephalitis has proven to be a significant cause of treatable movement disorder in children and to present a multifaceted link with herpes simplex encephalitis. The growing use of next-generation sequencing in both research and clinical practice has unravelled an expanding number of genes related to paediatric movement disorders as well as expanding spectrums of variable expressivity and phenotypic pleiotropy for various genes. Behavioural therapies have been proven efficacious in Tourette's syndrome and are likely to be helpful in complex motor stereotypies. Management of dystonia remains a clinical priority and challenge. The rapid advance of translational medicine has had major impacts on the field of paediatric movement disorders including diagnosis and treatment of these conditions. Video abstract [GRAPHICS]284437446Reta Lila Howard FoundationFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual de Campinas (UNICAMP)Parkinson's UKConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)GenusIpsenGuy's and St Thomas' Charity [G060708]Action Medical Research [GN2097]Dystonia SocietyFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP