The Current Status And Future Of Lc Column Technology: What The Experts Are Saying

High performance liquid chromatography (HPLC) and ultrahigh-pressure liquid chromatography (UHPLC) stationary-phase technology have arrived at a crossroads, with several competing approaches vying to become the standard column type for use in future routine separations. To understand the path forward of sub-2-mu m porous particles, superficially porous (core-shell) particles, silica monoliths, and polymeric monoliths, a survey of 14 leading HPLC-UHPLC column experts was conducted in June 2013. A series of questions was directed to the experts, and this report serves as a summary of their inputs on recent column advances, deficiencies and problems, instrument capabilities, and future directions of the technologies.3311404