Renal Cell Carcinoma: Histological Classification And Correlation With Imaging Findings [carcinoma De Células Renais: Classificação Histológica E Correlação Com Métodos De Imagem]

Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes. © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem.483166174Jemal, A., Siegel, R., Ward, E., Cancer statistics, 2008 (2008) CA Cancer J Clin., 58, pp. 71-96Ljunberg, B., Campbell, S.C., Cho, H.Y., The epidemiology of renal cell carcinoma (2011) Eur Urol., 60, pp. 615-621Lopez-Beltran, A., Scarpelli, M., Montironi, R., 2004 WHO classification of renal tumours of the adults (2006) Eur Urol., 49, pp. 798-805Decastro, G.J., McKiernan, J.M., Epidemiology, clinical staging, and presentation of renal cell carcinoma (2008) Urol Clin North Am., 35, pp. 581-592Dechet, C.B., Zincke, H., Sebo, T.J., Prospective analysis of computerized tomography and needle biopsy with permanent sectioning to determine the nature of solid renal masses in adults (2003) J Urol., 169, pp. 71-74Silverman, S.G., Gan, Y.U., Mortele, K.J., Renal masses in the adult patient: The role of percutaneous biopsy (2006) Radiology., 240, pp. 6-22Upton, M.P., Parker, R.A., Youmans, A., Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy (2005) J Immunother., 28, pp. 488-495Motzer, R.J., Hutson, T.E., Tomczak, P., Sunitinib versus interferon alfa in metastatic renal-cell carcinoma (2007) N Engl J Med., 356, pp. 115-124Escudier, B., Eisen, T., Stadler, W.M., Sorafenib in advanced clearcell renal-cell carcinoma (2007) N Engl J Med., 356, pp. 125-134Dutcher, J.P., Szczylik, C., Tannir, N., Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma (adv RCC) receiving temsirolimus (TEMSR) or interferon-alpha (IFN) [Abstract] (2007) J Clin Oncol., 25, p. 5033Lopez-Beltran, A., Carrasco, J.C., Cheng, L., 2009 update on the classification of renal epithelial tumors in adults (2009) Int J Urol., 16, pp. 432-443Delahunt, B., Srigley, J.R., Montironi, R., Advances in renal neoplasia: Recommendations from the 2012 International Society of Urological Pathology Consensus Conference (2014) Urology., 83, pp. 969-974Catalano, C., Fraioli, F., Laghi, A., High-resolution multidetector CT in the preoperative evaluation of patients with renal cell carcinoma (2003) AJR Am J Roentgenol., 180, pp. 1271-1277Vargas, H.A., Chaim, J., Lefkowitz, R.A., Renal cortical tumors: Use of multiphasic contrast-enhanced MR imaging to differentiate benign and malignant histologic subtypes (2012) Radiology., 264, pp. 779-788Pedrosa, I., Sun, M.R., Spencer, M., MR imaging of renal masses: Correlation with findings at surgery and pathologic analysis (2008) Radiographics., 28, pp. 985-1003Prasad, S.R., Humphrey, P.A., Catena, J.R., Common and uncommon histologic subtypes of renal cell carcinoma: Imaging spectrum with pathologic correlation (2006) Radiographics., 26, pp. 1795-1806Prando, A., Intratumotal fat in a renal cell carcinoma (1991) AJR Am J Roentgenol., 156, p. 871Sandrasegaran, K., Sundaram, C.P., Ramaswamy, R., Usefulness of diffusion-weighted imaging in the evaluation of renal masses (2010) AJR Am J Roentgenol., 194, pp. 438-445Feltrin, L.T., Ferreira, J.R., Mamere, A.E., Signs of hypervascularization at magnetic resonance imaging in bone metastases from renal cell carcinoma (2009) Radiol Bras., 42, pp. 155-157Yoshimitsu, K., Kakihara, D., Irie, H., Papillary renal carcinoma: Diagnostic approach by chemical shift gradient-echo and echo-planar MR imaging (2006) J Magn Reson Imaging., 23, pp. 339-344Lubensky, I.A., Schmidt, L., Zhuang, Z., Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype (1999) Am J Pathol., 155, pp. 517-526Egbert, N.D., Caoili, E.M., Cohan, R.H., Differentiation of papillary renal cell carcinoma subtypes on CT and MRI (2013) AJR Am J Roentgenol., 201, pp. 347-355Karlo, C.A., Donati, O.F., Burger, I.A., MR imaging of renal cortical tumours: Qualitative and quantitative chemical shift imaging parameters (2013) Eur Radiol., 23, pp. 1738-1744Liu, L., Qian, J., Singh, H., Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: An optimal and practical panel for differential diagnosis (2007) Arch Pathol Lab Med., 131, pp. 1290-1297Prando, A., Prando, D., Prando, P., Renal cell carcinoma: Unusual presentations (2006) Radiographics., 26, pp. 233-244Srigley, J.R., Eble, J.N., Collecting duct carcinoma of kidney (1998) Semin Diagn Pathol., 15, pp. 54-67Outwater, E.K., Bhatia, M., Siegelman, E.S., Lipid in renal clear cell carcinoma: Detection on opposed-phase gradient-echo MR images (1997) Radiology., 205, pp. 103-107Orsola, A., Trias, I., Raventós, C.X., Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma (2005) Urology., 65, pp. 49-54Murad, T., Komaiko, W., Oyasu, R., Multilocular cystic renal cell carcinoma (1991) Am J Clin Pathol., 95, pp. 633-637Eble, J.N., Bonsib, S.M., Extensively cystic renal neoplasms: Cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis (1998) Semin Diagn Pathol., 15, pp. 2-20Liu, Q., Galli, S., Srinivasan, R., Renal medullary carcinoma: Molecular, immunohistochemistry, and morphologic correlation (2013) Am J Surg Pathol., 37, pp. 368-374Khan, A., Thomas, N., Costello, B., Renal medullary carcinoma: Sonographic, computed tomography, magnetic resonance and angiographic findings (2000) Eur J Radiol., 35, pp. 1-7Lima, M.S., Barros-Silva, G.E., Pereira, R.A., The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney: A case report (2013) World J Surg Oncol., 11, p. 34Srigley, J.R., Delahunt, B., Uncommon and recently described renal carcinomas (2009) Mod Pathol., 22, pp. S2-S23Koo, H.J., Choi, H.J., Kim, M.H., Radiologic-pathologic correlation of renal cell carcinoma associated with Xp11.2 translocation (2013) Acta Radiol., 54, pp. 827-834Fleitz, J.M., Wootton-Gorges, S.L., Wyatt-Ashmead, J., Renal cell carcinoma in long-term survivors of advanced stage neuroblastoma in early childhood (2003) Pediatr Radiol., 33, pp. 540-545Cheville, J.C., Lohse, C.M., Zincke, H., Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma (2003) Am J Surg Pathol., 27, pp. 612-62