Endothelial Nitric Oxide Synthase Genotypes Modulate Peripheral Vasodilatory Properties After Myocardial Infarction

Background: Studies in population genetics suggest an important relationship between the eNOS G894T polymorphism and occurrence of acute myocardial infarction (AMI), with little known on its influence on the post-AMI period. Aim: To investigate the association of allelic variants produced by the G894T transversion in eNOS (rs1799983) with post-AMI variables. Methods: Cross-sectional analyses of anthropometric, clinical and laboratory assessments obtained within the first 24. h and after 5 and 30. days of the AMI event across T carriers and G homozygotes of eNOS in 371 consecutive cases of AMI with ST-segment elevation admitted to a Brazilian emergency service in cardiology. Genotypes were determined by polymerase chain reaction followed by enzymatic restriction. 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