Machado-Joseph disease or spinocerebellar ataxia 3 (MJD/SCA3) is a clinically heterogeneous, neurodegenerative disorder characterized by varying degrees of ataxia, ophthalmoplegia, peripheral neuropathy, pyramidal dysfunction and movement disorder. MJD/SCA3 is caused by a CAG repeat expansion mutation in the protein coding region of the ATXN3 gene located at chromosome 14q32.1. Current hypotheses regarding pathogenesis favor the view that mutated ataxin-3, with its polyglutamine expansion, is prone to adopt an abnormal conformation, engage in altered protein-protein interactions and aggregate. Expanded CAG repeat length correlates with the range and severity of the clinical manifestations and inversely correlates with age of disease onset. ...
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common autosomal domin...
Although clinical reports of Machado-Joseph disease have been increasing, its neuropathology is not ...
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease ...
Abstract Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represent...
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an incurable di...
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an incurable di...
Recent advances in molecular genetics has clarified the disease locus in the chromosomal mapping, in...
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is a neurodegenera...
Machado-Joseph Disease (MJD), also known as Spinocerebellar Ataxia 3, is a member of the polyglutarn...
Background: Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal d...
Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most...
Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most...
Machado-Joseph disease (SCA3/MJD) is the most common spinocerebellar ataxia worldwide, and particula...
Machado-Joseph disease (MJD/SCA3) is the most common form of dominantly inherited ataxia worldwide. ...
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common autosomal domin...
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common autosomal domin...
Although clinical reports of Machado-Joseph disease have been increasing, its neuropathology is not ...
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease ...
Abstract Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), represent...
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an incurable di...
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an incurable di...
Recent advances in molecular genetics has clarified the disease locus in the chromosomal mapping, in...
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is a neurodegenera...
Machado-Joseph Disease (MJD), also known as Spinocerebellar Ataxia 3, is a member of the polyglutarn...
Background: Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal d...
Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most...
Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most...
Machado-Joseph disease (SCA3/MJD) is the most common spinocerebellar ataxia worldwide, and particula...
Machado-Joseph disease (MJD/SCA3) is the most common form of dominantly inherited ataxia worldwide. ...
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common autosomal domin...
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is the most common autosomal domin...
Although clinical reports of Machado-Joseph disease have been increasing, its neuropathology is not ...
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease ...