Two alkaloids were isolated from the leaves of Cissampelos sympodialis; a bisbenzylisoquinoline compound named warifteine and a novel 8,14-dihydromorphinandienone alkaloid named milonine. The cytotoxic effects of these alkaloids were assayed in cultured hepatocytes and V79 fibroblasts. Three independent endpoint assays for cytotoxicity in vitro were used: the nucleic acid content (NAC), tetrazolium reduction (MTT) and neutral red uptake (NRU). Milonine was less toxic than warifteine in both cell cultures. The IC50 values determined in the three different viability assays were around 100 and 400 microM after milonine treatment of V79 cells or hepatocytes. IC50 values ranging from 10 to 35 microM were obtained for warifteine in the viability ...
In search of new antiviral compounds against Zika virus we conducted a bioassay-guided fractionation...
Objective: To study antiplasmodial and antioxidant activities of the isolation of alkaloids from the...
The cytotoxicity and the selective antiprotozoal activity of some Strychnos alkaloids, namely strych...
<p>The ethanolic extract of the leaves of <i>Cissampelos sympodialis</i> showed great pharmacologica...
Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically us...
Pyrrolizidine alkaloids were considered as the essential components in the toxicity of some composit...
The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychno...
Mitragyna speciosa Korth (Kratom), a herb of the Rubiaceae family is indigenous in southeast Asia ma...
Three new proaporphine alkaloids, cissamaline (4), cissamanine (5), and cissamdine (6), along with t...
Abstract: Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are histo...
Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoo...
The steroidal glycoalkaloid solamargine and its parent aglycone solasodine, isolated from Solanum pa...
AbstractBackgroundCissampelos sympodialis Eichl. (Menispermaceae) is used in folk medicine for the t...
AbstractFood allergy is a severe human disease with imminent risk of life. Cissampelos sympodialis (...
Bioassay-guided fractionation of Haplophyllum canaliculatum Boiss. (Rutaceae) extract resulted in is...
In search of new antiviral compounds against Zika virus we conducted a bioassay-guided fractionation...
Objective: To study antiplasmodial and antioxidant activities of the isolation of alkaloids from the...
The cytotoxicity and the selective antiprotozoal activity of some Strychnos alkaloids, namely strych...
<p>The ethanolic extract of the leaves of <i>Cissampelos sympodialis</i> showed great pharmacologica...
Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically us...
Pyrrolizidine alkaloids were considered as the essential components in the toxicity of some composit...
The cellular effects of three alkaloids isolated from STRYCHNOS USAMBARENSIS (melinonine F, strychno...
Mitragyna speciosa Korth (Kratom), a herb of the Rubiaceae family is indigenous in southeast Asia ma...
Three new proaporphine alkaloids, cissamaline (4), cissamanine (5), and cissamdine (6), along with t...
Abstract: Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are histo...
Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoo...
The steroidal glycoalkaloid solamargine and its parent aglycone solasodine, isolated from Solanum pa...
AbstractBackgroundCissampelos sympodialis Eichl. (Menispermaceae) is used in folk medicine for the t...
AbstractFood allergy is a severe human disease with imminent risk of life. Cissampelos sympodialis (...
Bioassay-guided fractionation of Haplophyllum canaliculatum Boiss. (Rutaceae) extract resulted in is...
In search of new antiviral compounds against Zika virus we conducted a bioassay-guided fractionation...
Objective: To study antiplasmodial and antioxidant activities of the isolation of alkaloids from the...
The cytotoxicity and the selective antiprotozoal activity of some Strychnos alkaloids, namely strych...