Add to ORKGThe p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and ASPP2 are specific activators of p53. To understand, if apoptosis-stimulating protein of p53 (ASPP) inactivation offers a selective advantage to tumors that have wild-type p53, we measured the mRNA expression of ASPP1 and ASPP2 in tumor cell lines retaining wide-type p53. In addition, the CpG island methylation status of ASPP1 gene and ASPP2 gene in the 5'-untranslated region was also investigated in order to understand the possible cause of abnormal expression of ASPP1 and ASPP2 in the tumor cell lines retaining wide-type p53. The data showed that mRNA expression of ASPP1 and ASPP2 is downregulated and CpG island tested is hypermethylated. These resu...
One of the most frequently mutated genes in human cancers, tumour suppressor p53 (TP53), can induce ...
The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and ...
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neo...
The p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and ASPP2 are...
AbstractThe p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and A...
原著Original ArticleThe p53 protein is one of the best-known tumor suppressors. Recently discovered AS...
We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-termin...
We have analyzed the regulation and expression of ASPP members, genes implicated in the regulation ...
The p53 protein is one of the best-known tumor suppressors. The recently identified ASPP family (apo...
The fundamental role of apoptosis in tumor prevention and the important role of p53 in this process ...
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups d...
Alternative splicing is a common physiologic mechanism to generate numerous distinct gene products f...
We recently showed that ASPP1 and ASPP2 stimulate the apoptotic function of p53. We show here that A...
UNLABELLED: The ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing...
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neo...
One of the most frequently mutated genes in human cancers, tumour suppressor p53 (TP53), can induce ...
The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and ...
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neo...
The p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and ASPP2 are...
AbstractThe p53 protein is one of the best-known tumour suppressors. Recently discovered ASPP1 and A...
原著Original ArticleThe p53 protein is one of the best-known tumor suppressors. Recently discovered AS...
We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-termin...
We have analyzed the regulation and expression of ASPP members, genes implicated in the regulation ...
The p53 protein is one of the best-known tumor suppressors. The recently identified ASPP family (apo...
The fundamental role of apoptosis in tumor prevention and the important role of p53 in this process ...
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups d...
Alternative splicing is a common physiologic mechanism to generate numerous distinct gene products f...
We recently showed that ASPP1 and ASPP2 stimulate the apoptotic function of p53. We show here that A...
UNLABELLED: The ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing...
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neo...
One of the most frequently mutated genes in human cancers, tumour suppressor p53 (TP53), can induce ...
The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and ...
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neo...