Monitoring the polymorphic transformation on the surface of carbamazepine tablets generated by heating using near-infrared chemical imaging and chemometric methodologies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)This work presents the monitoring of the polymorphic transformation of carbamazepine (form III to form I) in pharmaceutical formulations as tablets, generated by heating at a temperature of 140 degrees C for 7 h, with data acquisition in each hour. Near infrared chemical imaging in conjunction with chemometric procedures was used to evaluate the change on the distribution of each polymorph in the tablet surface. The concentration distribution maps of polymorphic forms I and III of carbamazepine in the tablet were estimated by matrix-augmented multivariate curve resolution (MCR) and parallel factor analysis (PARAFAC). The concentration profile as a function of time under heating allowed a dynamic study of the system. The results show that MCR was able to provide information about the polymorphic transformation of carbamazepine tablets in the dynamic process, generating distribution maps for each acquisition time. PARAFAC provided global information about the system, but it was not able to completely resolve the spectral components. (C) 2013 Elsevier B.V. All rights reserved.1309197Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq