Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein deletion and subsequent activation of the PI3K/Akt signaling pathway are common in cancer. Here we show that PTEN inactivation in human T cell acute lymphoblastic leukemia (T-ALL) cells is not always synonymous with PTEN gene lesions and diminished protein expression. Samples taken from patients with T-ALL at the time of diagnosis very frequently showed constitutive hyperactivation of the PI3K/Akt pathway. In contrast to immortalized cell lines, most primary T-ALL cells did not harbor PTEN gene alterations, displayed normal PTEN mR...
We examined the functional role of the phosphatidylinositol 3′-kinase pathway in the growth and surv...
textabstractBackground PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, ...
PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosi...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of p...
© 2014 Ferrata Storti Foundation. This is an open-access paperAdult B-cell acute lymphoblastic leuke...
Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphatidylinositol 3-kinase (...
T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations ...
SummaryMutations and inactivation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN...
Mutations and inactivation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) are o...
Loss of PTEN, a negative regulator of the phosphoinositide 3-kinase signaling pathway, is a frequent...
T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations ...
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better ...
To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT pathway to T-cell ac...
PTEN encodes a lipid phosphatase that is underexpressed in many cancers owing to deletions, mutation...
We examined the functional role of the phosphatidylinositol 3′-kinase pathway in the growth and surv...
textabstractBackground PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, ...
PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosi...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of p...
© 2014 Ferrata Storti Foundation. This is an open-access paperAdult B-cell acute lymphoblastic leuke...
Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphatidylinositol 3-kinase (...
T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations ...
SummaryMutations and inactivation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN...
Mutations and inactivation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) are o...
Loss of PTEN, a negative regulator of the phosphoinositide 3-kinase signaling pathway, is a frequent...
T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations ...
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better ...
To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT pathway to T-cell ac...
PTEN encodes a lipid phosphatase that is underexpressed in many cancers owing to deletions, mutation...
We examined the functional role of the phosphatidylinositol 3′-kinase pathway in the growth and surv...
textabstractBackground PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, ...
PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosi...