Modelling natamycin release from alginate/chitosan active films

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)In antimicrobial active films, the active agent is incorporated in the polymeric matrix and is released from the film to the product surface where most deterioration processes take place. In this study, films structured solely by alginate and by blends of alginate:chitosan (82.5:17.5 and 65:35) were obtained by casting. The film formulations received natamycin (4 and 8 g/100 g biopolymer) as antimicrobial agent. Films were characterised according to their thickness and morphology. Diffusion experiments in water indicated very slow release kinetics of the antimicrobial, being markedly hindered in the alginate and chitosan composite films, probably due to electrostatic interactions between chitosan and natamycin. Fickian diffusion prevailed and the diffusion coefficients found for the films varied from 2.6 x 10-11 to 2.5 x 10-12 cm2 s-1.474740746Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP [Proc. n. 2005/55499-3