An NMR tool for cyclodextrin selection in enantiomeric resolution by high-performance liquid chromatography

Complexation-induced chemical shifts and diffusion coefficients (HR-DOSY) of enantiomers with native and derivatized cyclodextrins were used for calculations of the apparent binding constants of three cyclohexanone inclusion complexes. Correlations between these data and high-performance liquid chromatography were established, revealing that this approach can be applied as an alternative method to predict enantiomeric discrimination. Copyright (C) 2002 John Wiley Sons, Ltd.40743344