Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations
- de Moraes, DS
- de Abreu, VA
- Rostelato-Ferreira, S
- Leite, GB
- da Cruz-Hofling, MA
- Travaglia-Cardoso, SR
- Hyslop, S
- Rodrigues-Simioni, L
DOIAbstract
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Venom (10-100 mu g/ml) from Bothrops alcatraz, a pitviper from the Alcatrazes Archipelago off the coast of southeastern Brazil, caused progressive, irreversible neuromuscular blockade in chick isolated biventer cervicis preparations. The venom also inhibited contractures to exogenous ACh (110 mu M) and KCl (20 mM), caused myofiber damage and increased creatine kinase release. Commercial bothropic antivenom raised against mainland Bothrops species neutralized the neuromuscular activity, depending on the venom concentration. (C) 2011 Elsevier Ltd. All rights reserved.592294299Coordenação de Aperfeiçoamento de ...
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