The MHC-based suppression theory (MBS) was first proposed by the author as a system for T cell control over a decade ago. At that time suppression of T cells was a deeply unpopular concept and it was not possible publish in widely read journals, so it is likely most visitors to this Website have never heard of it. However, T cell suppression is currently back in favour, this time called regulation, but there can be little doubt it is the same phenomenon. This treatise revision explores the relationship between T cells, MHC molecules and the peptides they carry. It proposes a paradigm shift concerning the reason for the extreme polymorphism of the MHC which has been hitherto focussed on peptide binding, but has here been proposed to prevent ...
International audienceThe rapamycin-inducible gene regulation system was designed to minimize immune...
textabstractThe human body is under constant siege of pathogens - bacteria, viruses, fungi and paras...
© 2012 Dr. Sidonia Barbara Guiomar EckleIn the adaptive immune response αβ T cell receptors (TCRs) e...
This treatise presents in detail a novel proposal that the tissue-type molecules are so varied and n...
A seminal discovery of major histocompatibility complex (MHC) restriction in T cell recognition by P...
The Standard model of T cell recognition asserts that T cell receptor (TCR) specificities are positi...
The immune system has evolved the capacity to react specifically with a very large number of foreign...
A great paradox in cellular immunology is how T cell allorecognition exists at high frequencies (up ...
Abstract MDSCs have been recognized in the last years as tolerogenic cells, potentially dangerous in...
Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen genes (HLA) in h...
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pa...
B and T lymphocytes of the immune system employ a highly effective diversity-generating machinery to...
The immunological surveillance hypothesis was formulated prior to the realization of the fact that a...
The T-cell branch of the immune system can respond to a virtu-ally infinite variety of antigens, in ...
MHC-encoded molecules govern adaptive immune responses by presenting peptides to T cell receptors (T...
International audienceThe rapamycin-inducible gene regulation system was designed to minimize immune...
textabstractThe human body is under constant siege of pathogens - bacteria, viruses, fungi and paras...
© 2012 Dr. Sidonia Barbara Guiomar EckleIn the adaptive immune response αβ T cell receptors (TCRs) e...
This treatise presents in detail a novel proposal that the tissue-type molecules are so varied and n...
A seminal discovery of major histocompatibility complex (MHC) restriction in T cell recognition by P...
The Standard model of T cell recognition asserts that T cell receptor (TCR) specificities are positi...
The immune system has evolved the capacity to react specifically with a very large number of foreign...
A great paradox in cellular immunology is how T cell allorecognition exists at high frequencies (up ...
Abstract MDSCs have been recognized in the last years as tolerogenic cells, potentially dangerous in...
Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen genes (HLA) in h...
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pa...
B and T lymphocytes of the immune system employ a highly effective diversity-generating machinery to...
The immunological surveillance hypothesis was formulated prior to the realization of the fact that a...
The T-cell branch of the immune system can respond to a virtu-ally infinite variety of antigens, in ...
MHC-encoded molecules govern adaptive immune responses by presenting peptides to T cell receptors (T...
International audienceThe rapamycin-inducible gene regulation system was designed to minimize immune...
textabstractThe human body is under constant siege of pathogens - bacteria, viruses, fungi and paras...
© 2012 Dr. Sidonia Barbara Guiomar EckleIn the adaptive immune response αβ T cell receptors (TCRs) e...