INTRODUCTION: Our objective was to evaluate the effect of epidermal growth factor receptor(s) (EGFR) density on the importation and nuclear localization of 111In-labeled diethylenetriaminepentaacetic acid human epidermal growth factor ([111In]DTPA-hEGF) in breast cancer (BC) cells in vitro and in tumor xenografts and normal tissues in vivo in athymic mice, as well as on its cytotoxicity and tumor and normal-tissue distribution. METHODS: The internalization and nuclear importation of [111In]DTPA-hEGF were measured in MCF-7, MDA-MB-231, BT-474 and MDA-MB-468 BC cells (10(4), 2 x 10(5), 6 x 10(5) and 10(6) EGFR/cell, respectively). The molecular size (Mr) distribution and immunoreactivity of nuclear radioactivity were characterized. Tumor and ...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
perturbation by receptor ligand(s), e.g., epidermal growth factor (EGF) and transforming growth fact...
The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting t...
Our objective was to determine whether the internalization and nuclear translocation of human epider...
UNLABELLED: (111)In-DTPA-human epidermal growth factor ((111)In-DTPA-hEGF [DTPA is diethylenetriamin...
grantor: University of TorontoThe overexpression of the epidermal growth factor receptor i...
111In-DTPA–human epidermal growth factor (111In-DTPA-hEGF [DTPA is diethylenetriaminepentaacetic aci...
netriaminepentaacetic acid human epidermal growth factor (111In-DTPA-hEGF) binds the epidermal growt...
Our objective was to compare 111In-labeled human epidermal growth factor (hEGF), a 53-amino acid pep...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
Receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR) are internalised f...
textabstractEpidermal growth factor (EGF) is a 53-aminoacid polypeptide (mol wt 6.045 K) that can in...
INTRODUCTION: Our objective was to define the relationships between tumor uptake of [(111)In]-IGF-1 ...
OBJECTIVE: Probing intranuclear proteins in breast cancer (BC) cells by using radiolabeled antibodie...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
perturbation by receptor ligand(s), e.g., epidermal growth factor (EGF) and transforming growth fact...
The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting t...
Our objective was to determine whether the internalization and nuclear translocation of human epider...
UNLABELLED: (111)In-DTPA-human epidermal growth factor ((111)In-DTPA-hEGF [DTPA is diethylenetriamin...
grantor: University of TorontoThe overexpression of the epidermal growth factor receptor i...
111In-DTPA–human epidermal growth factor (111In-DTPA-hEGF [DTPA is diethylenetriaminepentaacetic aci...
netriaminepentaacetic acid human epidermal growth factor (111In-DTPA-hEGF) binds the epidermal growt...
Our objective was to compare 111In-labeled human epidermal growth factor (hEGF), a 53-amino acid pep...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
Receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR) are internalised f...
textabstractEpidermal growth factor (EGF) is a 53-aminoacid polypeptide (mol wt 6.045 K) that can in...
INTRODUCTION: Our objective was to define the relationships between tumor uptake of [(111)In]-IGF-1 ...
OBJECTIVE: Probing intranuclear proteins in breast cancer (BC) cells by using radiolabeled antibodie...
[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells...
perturbation by receptor ligand(s), e.g., epidermal growth factor (EGF) and transforming growth fact...
The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting t...