Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)It is well established that dorsal root ganglion (DRG) cells synthesize prostaglandin. However, the role that prostaglandin plays in the inflammatory hyperalgesia of peripheral tissue has not been established. Recently, we have successfully established a technique to inject drugs (3 mu L) directly into the L5-DRG of rats, allowing in vivo identification of the role that DRG cell-derived COX-1 and COX-2 play in the development of inflammatory hyperalgesia of peripheral tissue. IL-1 beta (0.5 pg) or carrageenan (100 ng) was administered in the L5-peripheral field of rat hindpaw and mechanical hyperalgesia was evaluated after 3 h. Administration of a nonselective COX inhibitor (indom...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Activation of P2X3,2/3 receptors by end...
Lipid molecules play an important role in regulating the sensitivity of sensory neurons and enhancin...
The perception of pain - burning, aching and soreness - acts as a physiological warning that protect...
Peripheral inflammatory hyperalgesia depends on the sensitization of primary nociceptive neurons. In...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do ...
Blockade of prostaglandin (PG) production by COX inhibitors is the treatment of choice for inflammat...
Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hypera...
Increasingly, evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) have central act...
Immunocytochemical and morphometric techniques were used to quantify the distribution of cyclooxygen...
Background Recent studies show that inflammatory processes may contribute to neuropathic pain. Cyclo...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvime...
Inflammatory processes within the peripheral nervous system (PNS) are associated with symptoms of hy...
It was suggested that endocannabinoids are metabolized by cyclooxygenase (COX)-2 in the spinal cord ...
The aim of this study was to further validate our carrageenan-induced temporomanclibular joint (TMJ)...
Activation of P2X3,2/3 receptors by endogenous ATP contributes to the development of inflammatory hy...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Activation of P2X3,2/3 receptors by end...
Lipid molecules play an important role in regulating the sensitivity of sensory neurons and enhancin...
The perception of pain - burning, aching and soreness - acts as a physiological warning that protect...
Peripheral inflammatory hyperalgesia depends on the sensitization of primary nociceptive neurons. In...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do ...
Blockade of prostaglandin (PG) production by COX inhibitors is the treatment of choice for inflammat...
Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hypera...
Increasingly, evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) have central act...
Immunocytochemical and morphometric techniques were used to quantify the distribution of cyclooxygen...
Background Recent studies show that inflammatory processes may contribute to neuropathic pain. Cyclo...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvime...
Inflammatory processes within the peripheral nervous system (PNS) are associated with symptoms of hy...
It was suggested that endocannabinoids are metabolized by cyclooxygenase (COX)-2 in the spinal cord ...
The aim of this study was to further validate our carrageenan-induced temporomanclibular joint (TMJ)...
Activation of P2X3,2/3 receptors by endogenous ATP contributes to the development of inflammatory hy...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Activation of P2X3,2/3 receptors by end...
Lipid molecules play an important role in regulating the sensitivity of sensory neurons and enhancin...
The perception of pain - burning, aching and soreness - acts as a physiological warning that protect...