Anomalous diffusion of DNA on a supported cationic lipid membrane
- Chen-Ming Chang
- Yuk-Gyn Lau
- Shu-Ching Ou
- Tse-Yu Lin
- Wen-Tau Juan
DOIAbstract
We used fluorescence microscopy to investigate the diffusion dynamics of individual DNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNA on the membrane surface showed sub-diffusion associated with a slower DNA conformational relaxation at a short time scale. The evolution of contours of these non-entangled DNA at this short time scale was retained within a “hypothetical tube” of diameter $<1\ \mu \text{m}$ . Inhomogeneous DNA-surface interaction along the DNA contour, identified by total internal reflection fluorescence microscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane
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