Non-effect of p22-phox-930A/G polymorphism on end-organ damage in Brazilian hypertensive patients

The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system. 1,2 The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD( P) H oxidase-mediated oxidative stress and hypertension. 3,4 We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy.(2) Thus, the aim of the present report was to investigate the role of p22-phox -930A/G polymorphism on end-organ damage in hypertensive patients.21650450