Primary Oral And Perioral Amyloidosis Associated With Multiple Myeloma

Three years after being diagnosed with multiple myeloma, a patient sought treatment for swelling on the floor of the mouth, associated with hardening of the soft tissues on the right perioral region, loss of facial expression, and difficulty opening his mouth. The patient reported improvement following an incisional biopsy for microscopic diagnosis. Eighteen months later, the patient showed no clinical alterations.535340341Stoopler, E.T., Sollecito, T.P., Chen, S.Y., Amyloid deposition in the oral cavity: A retrospective study and review of the literature (2003) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 95, pp. 674-680Kyle, R.A., Linos, A., Beard, C.M., Linke, R.P., Gertz, M.A., O'Fallon, W.M., Kurland, L.T., Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989 (1992) Blood, 79, pp. 1817-1822Virchow, V.R., Ueber einem Gehirn and Rueckenmark des Menschen auf gefundene Substanz mit chemischen reaction der Cellulose (1854) Virchows Arch Pathol Anat, 6, pp. 135-138Raubenheimer, E.J., Dauth, J., De Coning, J.P., Multiple myeloma presenting with extensive oral and perioral amyloidosis (1986) Oral Surg Oral Med Oral Pathol, 61, pp. 492-497Salisbury III, P.L., Jacoway, J.R., Oral amyloidosis: A late complication of multiple myeloma (1983) Oral Surg Oral Med Oral Pathol, 56, pp. 48-50Raubenheimer, E.J., Dauth, J., Pretorius, F.J., Multiple myeloma and amyloidosis of the tongue (1988) J Oral Pathol, 17, pp. 554-559Flinck, W.G., Lawrence, F.R., Oral amyloidosis as initial symptom of multiple myeloma. A case report (1980) Oral Surg Oral Med Oral Pathol, 49, pp. 18-20Van Der Waal, R., Van Der Waal, R.I., Van De Scheur, M.R., Huijgens, P.C., Starink, T.M., Van Der Waal, I., Amyloidosis of the tongue as a paraneoplastic marker of plasma cell dyscrasia (2002) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 94, pp. 444-447Loh, F.C., Ravindranathan, N., Yeo, J.F., Amyloidosis with oral involvement. Case report (1990) Aust Dent J, 35, pp. 14-18Tongue, primary amyloidosis, and multiple myeloma (1994) Oral Surg Oral Med Oral Pathol, 77, pp. 121-125Van Der Wal, N., Henzen-Logmans, S., Van Der Kwast, W.A.M., Van Der Waal, I., Amyloidosis of the tongue: A clinical postmortem study (1984) J Oral Pathol, 13, pp. 632-639Rocken, C., Shakespeare, A., Pathology, diagnosis and pathogenesis of AA amyloidosis (2002) Virchows Arch, 440, pp. 111-122Kyle, R.A., Greipp, P.R., Amyloidosis (AL). Clinical and laboratory features in 229 cases (1983) Mayo Clin Proc, 58, pp. 665-683Kyle, R.A., Bayrd, E.D., (1976) The Monoclonal Gammopathies: Multiple Myeloma and Related Cell Disorders, , Springfield, IL: Charles C. Thoma