The aim of the present work was to load mitotane, an effective drug for adrenocortical carcinoma treatment, in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). The SLN and NLC were successfully prepared by high shear homogenization followed by hot high pressure homogenization. Formulations were composed of cetyl palmitate as the solid lipid for SLN, whereas for NLC PEGylated stearic acid was selected as solid lipid and medium chain triacylglycerols as the liquid lipid. Tween® 80 and Span® 85 were used as surfactants for all formulations. The particle size, zeta potential, polydispersity index (PI), encapsulation efficiency (EE), and loading capacity (LC) were evaluated. The SLN showed a mean particle size of 150 nm, ...
More than half of all people diagnosed with cancer receive chemotherapy. Unfortunately, most chemoth...
To develop solid lipid nanoparticles (SLNs) with a new lipid matrix for delivery of hydrophobic bioa...
During the past decade, the number of studies describing nanostructured lipid carriers (NLC)-based f...
accepted manuscriptThe adrenal cortical carcinoma (ACC) treatment, for which mitotane (o,p-DDD) is t...
WOS: 000271386300019Lipid matrix nanoparticles, such as solid lipid nanoparticles (SLN) and nanostru...
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded muc...
Solid lipid nanoparticles (SLN) had been increasingly investigated as a new drug delivery system. SL...
Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposom...
Recent advances in nanotechnology have led to the development of nano-scale drugs and delivery syste...
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded muc...
Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) w...
Hybrid lipid polymers significantly changed the postulation of low or less bioavailability of conven...
A major obstacle to the application of nanostructured lipid carriers (NLCs) as carriers for hydrophi...
Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility...
This study was aimed to evaluate the impact of surfactants used for nanostructured lipid carriers (N...
More than half of all people diagnosed with cancer receive chemotherapy. Unfortunately, most chemoth...
To develop solid lipid nanoparticles (SLNs) with a new lipid matrix for delivery of hydrophobic bioa...
During the past decade, the number of studies describing nanostructured lipid carriers (NLC)-based f...
accepted manuscriptThe adrenal cortical carcinoma (ACC) treatment, for which mitotane (o,p-DDD) is t...
WOS: 000271386300019Lipid matrix nanoparticles, such as solid lipid nanoparticles (SLN) and nanostru...
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded muc...
Solid lipid nanoparticles (SLN) had been increasingly investigated as a new drug delivery system. SL...
Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposom...
Recent advances in nanotechnology have led to the development of nano-scale drugs and delivery syste...
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded muc...
Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) w...
Hybrid lipid polymers significantly changed the postulation of low or less bioavailability of conven...
A major obstacle to the application of nanostructured lipid carriers (NLCs) as carriers for hydrophi...
Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility...
This study was aimed to evaluate the impact of surfactants used for nanostructured lipid carriers (N...
More than half of all people diagnosed with cancer receive chemotherapy. Unfortunately, most chemoth...
To develop solid lipid nanoparticles (SLNs) with a new lipid matrix for delivery of hydrophobic bioa...
During the past decade, the number of studies describing nanostructured lipid carriers (NLC)-based f...