Malignant Odontogenic Tumors: A Multicentric Latin American Study Of 25 Cases

Objective: The aim of this study was to show the epidemiological features of 25 malignant odontogenic tumors (MOT) in Latin America. Materials and Methods: We retrieved 25 cases of MOT out of 2142 odontogenic tumors, from four oral diagnostic centers in Latin America, and described the main clinical and pathological characteristics. Results: A total of 19 cases were carcinomas, including eight ameloblastic carcinomas, five primary intra-osseous squamous cell carcinomas, three clear cell odontogenic carcinomas and three ghost cell odontogenic carcinomas. All six sarcomas corresponded to ameloblastic fibrosarcoma. Thirteen cases occurred in men and 12 in women, age ranged from 7 to 77 years old, with a mean of 41.4 years. The average age of patients with carcinomas and sarcomas were 48.53 and 19 years old, respectively. Conclusion: As malignant odontogenic tumors are very rare, this series helps to better clarify their relative frequency, predominant subtypes, and clinical characteristics in Latin America. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.204380385Adebayo, E.T., Ajike, S.O., Adekeye, E.O., A review of 318 odontogenic tumors in Kaduna, Nigeria (2005) J Oral Maxillofac Surg, 63, pp. 811-819Akrish, S., Buchner, A., Shoshani, Y., Vered, M., Dayan, D., Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma (2007) J Oral Maxillofac Surg, 65, pp. 777-783Arashiyama, T., Kodama, Y., Kobayashi, T., Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible (2012) Oral Surg Oral Med Oral Pathol Oral Radiol, 114, pp. e35-e40Arotiba, J.T., Ogunbiyi, J.O., Obiechina, A.E., Odontogenic tumors: a 15-year review from Ibadan, Nigeria (1997) Br J Oral Maxillofac Surg, 35, pp. 363-367Avelar, R.L., Antunes, A.A., Santos Tde, S., Andrade, E.S., Dourado, E., Odontogenic tumors: clinical and pathology study of 238 cases (2008) Braz J Otorhinolaryngol, 74, pp. 668-673Barnes, L., Eveson, J.W., Reichart, P.A., Sidransky, D., (2005) World health organization classification of tumours: pathology and genetics of tumours of the head and neck, , eds IARC: LyonBello, I.O., Alanen, K., Slootweg, P.J., Salo, T., Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma (2009) Oral Oncol, 45, pp. 760-765Bilodeau, E.A., Hoschar, A.P., Barnes, E.L., Hunt, J.L., Seethala, R.R., Clear cell carcinoma and clear cell odontogenic carcinoma: a comparative clinicopathologic and immunohistochemical study (2011) Head Neck Pathol, 5, pp. 101-107Bodner, L., Manor, E., Shear, M., van der Waal, I., Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases (2011) J Oral Pathol Med, 40, pp. 733-738Bologna-Molina, R., Mosqueda-Taylor, A., Lopez-Corella, E., Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma (2009) Pathol Int, 59, pp. 229-233Bregni, R.C., Taylor, A.M., García, A.M., Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature (2001) J Oral Pathol Med, 30, pp. 316-320Buchner, A., Merrell, P.W., Carpenter, W.M., Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world (2006) J Oral Maxillofac Surg, 64, pp. 1343-1352Chaisuparat, R., Sawangarun, W., Scheper, M.A., A clinicopathological study of malignant odontogenic tumours (2012) Histopathology, 61, pp. 107-112da-Costa, D.O., Maurício, A.S., de-Faria, P.A., Odontogenic tumors: a retrospective study of four Brazilian diagnostic pathology centers (2012) Med Oral Patol Oral Cir Bucal, 17, pp. e389-e394Daley, T.D., Wysocki, G.P., Pringle, G.A., Relative incidence of odontogenic tumors and jaw cysts in a Canadian population (1994) Oral Surg Oral Med Oral Pathol, 77, pp. 276-280Demoor-Goldschmidt, C., Minard-Colin, V., Cassagneau, E., Ameloblastic fibrosarcoma of the mandible: report of 2 chemosensitive pediatric cases (2012) J Pediatr Hematol Oncol, 34, pp. e72-e76Dissanayake, R.K., Jayasooriya, P.R., Siriwardena, D.J., Tilakaratne, W.M., Review of metastasizing (malignant) ameloblastoma (METAM): pattern of metastasis and treatment (2011) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, pp. 734-741El-Gehani, R., Orafi, M., Elarbi, M., Subhashraj, K., Benign tumours of orofacial region at Benghazi, Libya: a study of 405 cases (2009) J Craniomaxillofac Surg, 37, pp. 370-375Ellis, G.L., Shmookler, B.M., Aggressive (malignant?) epithelial odontogenic ghost cell tumor (1986) Oral Surg Oral Med Oral Pathol, 61, pp. 471-478Fernandes, A.M., Duarte, E.C., Pimenta, F.J., Odontogenic tumors: a study of 340 cases in a Brazilian population (2005) J Oral Pathol Med, 34, pp. 583-587Gallego, L., Junquera, L., Villarreal, P., Fresno, M.F., Primary de novo intraosseous carcinoma: report of a new case (2010) Med Oral Patol Oral Cir Bucal, 15, pp. e48-e51Goldenberg, D., Sciubba, J., Koch, W., Tufano, R.P., Malignant odontogenic tumors: a 22-year experience (2004) Laryngoscope, 114, pp. 1770-1774Grodjesk, J.E., Dolinsky, H.B., Schneider, L.C., Dolinsky, E.H., Doyle, J.L., Odontogenic ghost cell carcinoma (1987) Oral Surg Oral Med Oral Pathol, 63, pp. 576-581Günhan, O., Erseven, G., Ruacan, S., Odontogenic tumors. A series of 409 cases (1990) Aust Dent J, 35, pp. 518-522Huang, J.W., Luo, H.Y., Li, Q., Li, T.J., Primary intraosseous squamous cell carcinoma of the jaws Clinicopathologic presentation and prognostic factors (2009) Arch Pathol Lab Med, 133, pp. 1834-1840Jing, W., Xuan, M., Lin, Y., Odontogenic tumors: a retrospective study of 1642 cases in a Chinese population (2007) Int J Oral Maxillofac Surg, 36, pp. 20-25Karakida, K., Aoki, T., Sakamoto, H., Ameloblastic carcinoma, secondary type: a case report (2010) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 110, pp. e33-e37Kobayashi, K., Murakami, R., Fujii, T., Hirano, A., Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: case report and review of the literature (2005) J Craniomaxillofac Surg, 33, pp. 352-355Kousar, A., Hosein, M.M., Ahmed, Z., Minhas, K., Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: case report and literature review (2009) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108, pp. e80-e85Ladeinde, A.L., Ajayi, O.F., Ogunlewe, M.O., Odontogenic tumors: a review of 319 cases in a Nigeriam teaching hospital (2005) Oral Surg Oral Med Oral Pathol Osal Radiol Endod, 99, pp. 191-195Lai, J., Blanas, N., Higgins, K., Klieb, H., Ameloblastic fibrosarcoma: report of a case, study of immunophenotype, and comprehensive review of the literature (2012) J Oral Maxillofac Surg, 70, pp. 2007-2012Li, B.H., Cho, Y.A., Kim, S.M., Recurrent odontogenic ghost cell carcinoma (OGCC) at a reconstructed fibular flap: a case report with immunohistochemical findings (2011) Med Oral Patol Oral Cir Bucal, 16, pp. e651-e656Lu, Y., Xuan, M., Takata, T., Odontogenic tumors. A demographic study of 759 cases in a Chinese population (1998) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 86, pp. 707-714Lu, Y., Mock, D., Takata, T., Jordan, R.C., Odontogenic ghost cell carcinoma: report of four new cases and review of the literature (1999) J Oral Pathol Med, 28, pp. 323-329Luo, H.Y., Li, T.J., Odontogenic tumors: a study of 1309 cases in a Chinese population (2009) Oral Oncol, 45, pp. 706-711Mainenti, P., Oliveira, G.S., Valério, J.B., Ameloblastic fibro-odontosarcoma: a case report (2009) Int J Oral Maxillofac Surg, 38, pp. 289-292McCoy, B.P., Carroll, O., Hall, M.K.J.M., Carcinoma arising in a dentinogenic ghost cell tumor (1992) Oral Surg Oral Med Oral Pathol, 74, pp. 371-378Mosqueda-Taylor, A., Meneses-García, A., Ruíz-Godoy Rivera, L.M., Suárez-Roa, M.d.L., Clear cell odontogenic carcinoma of the mandible (2002) J Oral Pathol Med, 31, pp. 439-441Mosqueda Taylor, A., Meneses García, A., Ruíz-Godoy Rivera, L.M., Suárez Roa Mde, L., Luna Ortiz, K., Malignant odontogenic tumors. A retrospective and collaborative study of seven cases (2003) Med Oral, 8, pp. 110-121Mosqueda-Taylor, A., New findings and controversies in odontogenic tumors (2008) Med Oral Patol Cir Bucal, 13, pp. e555-e558Mosqueda-Taylor, A., Ledesma-Montes, C., Caballero Sandoval, S., Portilla Robertson, J., Ruíz-Godoy Rivera, L.M., Meneses-García, A., Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases (1997) Oral Surg Oral Med Oral Pathol Oral Radiol, 84, pp. 672-675Noordhoek, R., Pizer, M.E., Laskin, D.M., Ameloblastic fibrosarcoma of the mandible: treatment, long-term follow-up, and subsequent reconstruction of a case (2012) J Oral Maxillofac Surg, 70, pp. 2930-2935Ochsenius, G., Ortega, A., Godoy, L., Peñafiel, C., Escobar, E., Odontogenic tumors in Chile: a study of 362 cases (2002) J Oral Pathol Med, 31, pp. 415-420Odukoya, O., Odontogenic tumors: analysis of 289 Nigerian cases (1995) J Oral Pathol Med, 24, pp. 454-457Ogunsalu, C.O., Odontogenic tumors from two centres in Jamaica. A 15-year review (2003) West Indian Med J, 52, pp. 285-289Okada, H., Yamamoto, H., Tilakaratne, W.M., Odontogenic tumors in Sri Lanka: analysis of 226 cases (2007) J Oral Maxillofac Surg, 65, pp. 875-882Olgac, V., Koseoglu, B.G., Aksakalli, N., Odontogenic tumors in Istanbul: 527 cases (2006) Br J Oral Maxillofac Surg, 44, pp. 386-388Osterne, R.L., Brito, R.G., Alves, A.P., Cavalcante, R.B., Sousa, F.B., Odontogenic tumors: a 5-year retrospective study in a Brazilian population and analysis of 3406 cases reported in the literature (2011) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, pp. 474-481Otero, D., Lourenço, S.Q., Ruiz-Ávila, I., Expression of proliferative markers in ameloblastomas and malignant odontogenic tumors (2013) Oral Dis, 19, pp. 360-365Pontes, H.A., Pontes, F.S., Silva, B.S., Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma (2010) Ann Diagn Pathol, 14, pp. 447-452Regezi, J.A., Kerr, D.A., Courtney, R.M., Odontogenic tumors: analysis of 706 cases (1978) J Oral Surg, 36, pp. 771-778Saghravanian, N., Jafarzadeh, H., Bashardoost, N., Pahlavan, N., Shirinbak, I., Odontogenic tumors in an Iranian population: a 30-year evaluation (2010) J Oral Sci, 52, pp. 391-396Santos, J.N., Pinto, L.P., de Figueredo, C.R., de Souza, L.B., Odontogenic tumors: analysis of 127 cases (2001) Pesqui Odontol Bras, 15, pp. 308-313Servato, J.P., Prieto-Oliveira, P., de Faria, P.R., Loyola, A.M., Cardoso, S.V., Odontogenic tumours: 240 cases diagnosed over 31 years at a Brazilian university and a review of international literature (2012) Int J Oral Maxillofac Surg, 42, pp. 288-293Simon, E.N., Stoelinga, P.J., Vuhahula, E., Ngassapa, D., Odontogenic tumours and tumour-like lesions in Tanzania (2002) East Afr Med J, 79, pp. 3-7Simon, E.N., Merkx, M.A., Vuhahula, E., Ngassapa, D., Stoelinga, P.J., A 4-year prospective study on epidemiology and clinicopathological presentation of odontogenic tumors in Tanzania (2005) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99, pp. 598-602Slater, L.J., Odontogenic malignancies (2004) Oral Maxillofac Surg Clin North Am, 16, pp. 409-424Sriram, G., Shetty, R.P., Odontogenic tumors: a study of 250 cases in an Indian teaching hospital (2008) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 105, pp. e14-e21Tamme, T., Soots, M., Kulla, A., Odontogenic tumors, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia (2004) J Craniomaxillofac Surg, 32, pp. 161-165Tawfik, M.A., Zyada, M.M., Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases (2010) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109, pp. e67-e73Werle, H., Blake, F.A., Reichelt, U., Schmelzle, R., Heiland, M., Clear-cell odontogenic carcinoma: a new case and long-term follow-up of an old case, and review of the literature (2009) J Oral Maxillofac Surg, 67, pp. 1342-1348Xavier, F.C., Rodini, C.O., Ramalho, L.M., Sarmento, V.A., Nunes, F.D., de Sousa, S.C., Clear cell odontogenic carcinoma: case report with immunohistochemical findings adding support to the challenging diagnosis (2008) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106, pp. 403-410Yoon, H.J., Hong, S.P., Lee, J.I., Lee, S.S., Hong, S.D., Ameloblastic carcinoma: an analysis of 6 cases with review of the literature (2009) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108, pp. 904-913Zabolinejad, N., Hiradfar, M., Anvari, K., Razavi, A.S., Ameloblastic fibrosarcoma of the maxillary sinus in an infant: a case report with long-term follow-up (2008) J Pediatr Surg, 43, pp. e5-e