Isoniazid Induced Hepatic Failure. A Case Report [insuficiencia Hepatica Pelo Uso De Isoniazida. Relato De Caso+]

Isoniazid and pyrazinamide are both well-known hepatotoxic drugs. When isoniazid is used, the hepatic lesion appears before than when pyrazinamide is used. This paper intents to relate a case of a 5-month-old patient who had lungs' and meningeal tuberculosis and who developed toxic hepatitis accomplished by hepatic failure while he was being treated with isoniazid, pyrazinamide and rifampicin. The clinic manifestations and the laboratory alterations were detected in the fifth day of treatment and the recovery was fast; and almost complete by the end of the first week, in which the use of isoniazid had been suspended. Although it was necessary to take the patient to the intensive care unit, he had a good recovery, without sequels.3717275Durand, F., Bernuau, J., Pessayre, D., Samuel, D., Belaiche, J., Degott, C., Bismuth, H., Benhamou, J.P., Deleterious influence of pyrazinamide on the outcome of patients with fulminant or subfulminant liver failure during antituberculous treatment including isoniazid (1995) Hepatology, 21, p. 929Durand, F., Jebrak, G., Pessayre, D., Fournier, M., Hepatotoxicity of antitubercular treatments (1996) Drug Saf, 15, p. 394Franks, A.L., Binkin, N.J., Saider, D.E., Isoniazid hepatitis among pregnant and postpartum Hispanic patients (1989) Public Health Rep, 104, p. 151Furet, Y., Metman, E.H., Bertrand, J., Hepatite mixte a la rifampycine (1986) Therapie, 41, p. 405McDermont, J., Ormond, L., Muschenheim, C., Pyrazinamide and isoniazid in tuberculosis (1954) Am Rev Tuberc, 69, p. 319Nolan, C.M., Sandblom, R.E., Thummel, K.E., Hepatotoxicity associated with acetominophem usage in-patients receiving multiple drug therapy for tuberculosis (1994) Chest, 105, p. 408Ormerod, L.P., Kkinner, C., Wales, J., Hepatotoxicity of antituberculous drugs (1996) Thorax, 51, p. 111Ozick, L.A., Lee, T.P., Jacob, L., Early hepatotoxity from antituberculous treatment in alcoholics and AIDS patients (1991) Hepatology, 14, p. 275Pessayre, D., Bentata, M., Degott, C., Nouel, O., Miguet, J.P., Rueff, B., Benhamou, J.P., Isoniazid-rifampicin induced fulminant hepatitis: A possible consequence of hepatotoxicity by enzyme induction (1977) Gastroenterology, 72, p. 284Sherlock, S., Fígado e drogas (1988) Doenças Do Fígado E Do Sistema Biliar. 7. Ed., pp. 280-308. , Sherlock S. Rio de JaneiroGuanabara KooganClinical trial of six-month regimens of chemotherapy given intermittently in the continuation phase of treatment of pulmonary tuberculosis (1985) Am Rev Respir Dis, 132, p. 374Snider, D.E., Caras, G.J., Isoniazid associated hepatitis death - A review of available information (1992) Am Rev Respir Dis, 145, p. 494Wu, J.C., Lee, S.D., Yeh, P.F., Isoniazid rifampicin induced hepatitis in hepatitis B carriers (1990) Gastroenterology, 98, p. 50