Tif4 Varnish - A 19f-nmr Stability Study And Enamel Reactivity Evaluation

The aim of this study was to develop a titanium tetrafluoride (TiF 4) varnish and evaluate the stability of the formulation and its reactivity with dental enamel. The varnish was prepared in a resinous matrix using ethanol 96% as solvent. Samples (n=45) were aged at 65°C and 30% of relativity humidity (RE n°01/05 - ANVISA) and after 3, 6, 9 and 12 months, nine samples were removed for evaluation and compared with fresh samples. Chemical stability of TiF4 varnish was determinate by 19F-NMR and the reactivity of the formulation was quantified by formation of fluoride loosely (CaF2) and firmly bound (fluorapatite; FA) to enamel. For reactivity comparisons, a varnish without TiF4 was used as control. The loss of soluble fluoride was about 0.9% after one year of storage. The values of the reactivity (mean±S.D.) of fresh, aged at 3, 6, 9 and 12 months and control samples were: CaF2 (μgF/mm 2): 89.3±27.5a; 54.5±14.3b; 51.2±29.8b; 69.3±21.3a; 48.0±27. 4b; 0.10±0.07c, FA (μg F/g): 2477.5±1044.0a; 2484.8±992.0a; 2580.0±1383.9a; 2517.2±929.9a; 2121.0±1059.2a; 330.0±180.0b, respectively. Means followed by distinct letters were statistically different (p<0.05). After one year of storage, the formulation was chemically stable and the levels of FA were maintained. However there was an initial decrease in the ability to form CaF2. © 2008 Pharmaceutical Society of Japan.561139141Shrestha, B.M., Mundorff, S.A., Basil, G.B., (1972) J. Dent. Res, 51, pp. 1561-1566Vieira, A., Ruben, J.R., Huysmans, M.C., (2005) Caries Res, 39, pp. 371-379Laptash, N.M., Fedotov, M.A., Maslennikova, I.G., (2004) J. Struct. Chem, 45, pp. 74-82Buslaev, Y.A., Dyer, D.S., Ragsdale, R.O., (1967) Inorg. Chem, 6, pp. 2208-2212Curzon, M.E.J., Cutress, T.W., (1983) Trace Elements and Dental Disease, , ed. by Wright J, PSG Inc, BristolRagsdale, R.O., Stewart, B.B., (1963) Inorg. Chem, 2, pp. 1002-1004Wei, S.H.Y., Soboroff, D.M., Wefel, J.S., (1976) J. Dent. Res, 55, pp. 426-431Marion, S.P., Thomas, A.W., (1946) J. Colloid. Sci, 1, pp. 221-234ANVISA - Resolution RE no 1, July 29, 2005. Available in: http://elegis.anvisa.gov.br/leisref/public/showAct.php?id=18109&word=, Access in November, 2005Calavaska, V., Moreno, E.C., Brudevold, F., (1975) Arch. Oral. Biol, 20, pp. 333-339Marinho, V.C.C., Higgins, J.P.T., Logan, S., Sheiham, A., (2006) The Cochrane Library, (4). , Oxford: Update SoftwareMarinho, V.C.C., Higgins, J.P.T., Logan, S., Sheiham, A., (2006) The Cochrane Library, (4). , Oxford: Update SoftwareMarinho, V.C.C., Higgins, J.P.T., Logan, S., Sheiham, A., (2006) The Cochrane Library, (4). , Oxford: Update SoftwareMarinho, V.C.C., Higgins, J.P.T., Logan, S., Sheiham, A., (2006) The Cochrane Library, (4). , Oxford: Update SoftwareDyer, D.S., Ragsdale, R.O., (1969) Inorg. Chem, 8, pp. 1116-1120Ragsdale, R.O., Stewart, B.B., (1964) Proc. Chem. Soc, 1964, p. 194Ögaard, B., (2001) Caries Res, 35, pp. 40-44White, D.J., Nancollas, G.H., (1990) J. Dent. Res, 69, pp. 587-594Dyer, D.S., Ragsdale, R.O., (1967) Inorg. Chem, 6, pp. 8-11Serre, C., Corbiere, T., Lorentz, C., Taulelle, F., Férey, G., (2002) Chem. Mater, 14, pp. 4938-494