The Repair Process In Tooth Extraction Wounds After Implantation Of Microcrystalline Collagen Fragments. Histological Study In Rats [processo De Reparação Em Feridas De Extracção Dentária, Após Implante De Fragmentos De Colagénio Microcristalino. Estudo Histológico Em Ratos.]

The author studied histologically, the healing process after dental extraction in rats which sockets were filled with fragments of microcrystalline collagen. Thirty six rats (Rattus Novergicus, albinus, Wistar), young, male, weighting from 90 to 110 g and separated into two groups, control and experimental, of eighteen animal each. All animals were anaesthetized with 10% cloral hidrate, 3 ml/Kg body weight and the right maxillary incisors were extracted. In control animal the sockets were sutured after clot filling, and the experimental sockets were sutured after filling with microcrystalline collagen. Three animals of each group were killed after periods of 1, 3, 6, 14, 21 and 24 days after surgery. The following conclusions were drawn: 1. Microcrystalline collagen caused an evident inflammatory reaction in the inicial phases of the healing process of the sockets. 2. Microcrystalline collagen was biodegraded 6 to 14 days after surgery. 3. Microcrystalline collagen delayed the repair process of the sockets.31295102DOE; U.S. Department of Energy; NSF; U.S. Department of Energ