Synthesis And Characterizations Of Poly (lactic Acid) By Ring-opening Polymerization For Biomedical Applications

The development of biomaterials for application in medicine is one of the great challenges of research in material science. The poly (a-hydroxy acids) are the principal biodegradable and bioresorbable polymers used in tissue engineering. Among the biomaterials (biopolymers) used in the medical field, the poly (lactic acid) (PLA) has received significant attention. It is produced from lactic acid, a naturally occurring organic acid that can be produced by fermentation. The attractive price and commercial availability of lactic acid are important reasons for PLA development. PLA and its copolymers are being used in biomedical area in the form of implants or devices due to its excellent biocompatibility and biodegradability. In this study, lactide was synthesized and Poly lactic acid produced. The objective of this study was to investigate the PLA production in laboratory scale. Characterization by FTIR of the lactide and PLA production was made to confirm the polymerization and a possible use as biomaterial. © 2014, AIDIC Servizi S.r.l.38331336Auras, R., Harte, B., Selke, S., An overview of polylactides as packaging materials (2004) Macromolecular Bioscience, 4 (9), pp. 835-864. , DOI 10.1002/mabi.200400043Benicewicz, B.C., Hopper, P.K., Review: Polymers for absorbable surgical sutures - Part II (1991) Journal of Bioactive and Compatible Polymers, 1, pp. 64-94Bouapao, L., Tsuji, H., Tashiro, K., Zhang, J., Hanesaka, M., Crystallization, spherulite growth, and structure of blends of crystalline and amorphous poly(lactide)s (2007) Polymer, 50, pp. 4007-4017Cheng, Y., Deng, S., Chen, P., Ruan, R., Polylactic acid (PLA) synthesis and modifications: A review (2009) Frontiers of Chemistry in China, 4, pp. 259-264Davis, S.S., Illum, L., Stolnik, S., Polymers in drug delivery (1996) Current Opinion in Colloid & Interface Science, 1, pp. 660-666Drumright, R.E., Gruber, P.R., Henton, D.E., Polylactic acid technology (2000) Advanced Materials, 12 (23), pp. 1841-1846. , DOI 10.1002/1521-4095(200012)12:233.0.CO;2-EFreed, L.E., Engelmayr, Jr.G.C., Borenstein, J.T., Moutos, F.T., Guilak, F., Advanced material strategies for tissue engineering scaffolds (2009) Advanced Materials, 21, pp. 3410-3418Fukushima, K., Kimura, Y., An efficient solid-state polycondensation method for synthesizing stereocomplexed poly(lactic acid)s with high molecular weight (2008) Journal of Polymer Science Part A: Polymer Chemistry, 46, pp. 3714-3722Griffith, L.G., Polymeric biomaterials (2000) Acta Materialia, 48 (1), pp. 263-277. , www.faostat.fao.org, DOI 10.1016/S1359-6454(99)00299-2Gupta, B., Revagade, N., Hilborn, J., Poly(lactic acid) fiber: An overview (2007) Progress in Polymer Science (Oxford), 32 (4), pp. 455-482. , DOI 10.1016/j.progpolymsci.2007.01.005, PII S007967000700007XHu, J., Sun, X., Ma, H., Xie, C., Eugene Chen, Y., Ma, P.X., Porous nanofibrous PLLA scaffolds for vascular tissue engineering (2012) Biomaterials, 31, pp. 7971-7977Lim, L.T., Auras, R., Rubino, M., Processing technologies for poly(lactic acid) (2008) Progress in Polymer Science, 33, pp. 820-852Nampoothiri, K.M., Nair, N.R., John, R.P., An overview of the recent developments in polylactide (PLA) research (2010) Bioresource Technology, 101, pp. 8493-8501Nikolic, L., Ristic, I., Adnadjevic, B., Nikolic, V., Jovanovic, J., Stankovic, M., Novel microwave- assisted synthesis of poly(D,L-lactide): The influence of monomer/initiator molar ratio on the product properties (2010) Sensors, 10, pp. 5063-5073Saviolilopes, M., Jardini, A.L., Maciel, F.R., Poly (lactic acid) production for tissue engineering applications (2012) Procedia Engineering, 42, pp. 1402-1413Valonen, P.K., Moutos, F.T., Kusanagi, A., Moretti, M.G., Diekman, B.O., Welter, J.F., Caplan, A.I., Freed, L.E., In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly (3-caprolactone) scaffolds (2010) Biomaterials, 31, pp. 2193-2200Yamane, H., Sasai, K., Effect of the addition of poly(D-lactic acid) on the thermal property of poly(L-lactic acid) (2003) Polymer, 44 (8), pp. 2569-2575. , DOI 10.1016/S0032-3861(03)00092-2Yoo, D.K., Kim, D., Synthesis of lactide from oligomeric PLA: Effects of temperature, pressure, and catalyst (2006) Macromolecular Research, 14, pp. 510-51