Koninginins, Phospholipase A2 Inhibitors From Endophytic Fungus Trichoderma Koningii

Many isolated compounds from endophytic fungus have been useful to human beings, mainly those with medicinal applications and particularly those that can be used in inflammatory processes. Trichoderma fungi produce substances known as koninginins that have great structural similarity to compounds like flavonoids and vitamin E, which are able to inhibit the phospholipase A2 (PLA2). In this work, koninginins A, E and F (KonA, KonE and KonF, respectivamente) isolated from Trichoderma koningii had their capabilities of inhibiting edema-inducing, myotoxic and enzymatic activities of the total venom of Bothrops jararacussu (jararacuçu) snake analyzed, as well as one of its homolog forms of phospholipases A2 (bjPLA2-group IIB) and human secreted PLA2 protein fusion (hsPLA2-group IIA). KonA was not efficient in inhibiting the three activities analyzed in all the tests performed. 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