Large Infiltration Of Chronic Lymphocytic Leukemia In The Mandibular Region

Orofacial complications of leukemia include lymphadenopathy, gingival bleeding, petechiae, ulceration, gingival enlargement and infections. Chronic lymphocytic leukemia (CLL) is the most prevalent type of adult lymphoproliferative disorder, but oral manifestations are uncommon. We describe a rare case of extensive mandibular infiltration in chronic lymphocytic leukemia. © 2004 Elsevier Ltd. All rights reserved.4224951McKenna, S.J., Leukemia (2000) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89 (2), pp. 137-139Rai, K.R., Keating, M.J., Chronic lymphocytic leukemia (2000) Cancer Medicine, , R.C. Bast Jr. D.W. Kufe R.E. Pollock 5th ed B.C. Decker Inc. Ontario*et alKendrick, R.W., Schwartz, H.C., Richter's syndrome presenting as a facial swelling (1983) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 56 (3), pp. 301-304Nakamura, N., Abe, M., Richter syndrome in B-cell chronic lymphocytic leukemia (2003) Pathol Int., 53 (4), pp. 195-203Dreizen, S., McCredie, K.B., Keating, M.J., Luna, M.A., Malignant gingival and skin "infiltrates" in adult leukemia (1983) Oral Surg Oral Med Oral Pathol, 55 (6), pp. 572-579Porter, S.R., Matthews, R.W., Scully, C., Chronic lymphocytic leukaemia with gingival and palatal deposits (1994) J Clin Periodontol, 21 (8), pp. 559-561Presant, C.A., Safdar, S.H., Cherrick, H., Gingival leukemic infiltration in chronic lymphocytic leukemia (1973) Oral Surg Oral Med Oral Pathol, 36 (5), pp. 672-674McLaughin, P., Hagemeister, F.B., Ramaguera, J.E., Fludarabine, mitoxantrone, and dexamethasone: An effective new regimen for indolent lymphoma (1996) J Clin Oncol, 14 (4), pp. 1262-1268Cohen-Kerem, R., Quitt, M., Greenberg, E., Braverman, I., Head and neck manifestations of B-cell chronic lymphocytic leukemia (2000) Otolaryngol Head Neck Surg, 123 (6), pp. 784-785Wentz, F.M., Anday, G., Orban, B., Histopathologic changes in the gingiva in leukemia (1949) J Periodontol, 20, pp. 119-128Chaundhry, A.P., Sabes, W.R., Gorlin, R.J., Unusual oral manifestations of chronic lymphatic leukemia. Report of a case (1962) Oral Surg Oral Med Oral Pathol, 15 (4), pp. 446-449Schaedel, R., Goldberg, M.H., Chronic lymphocytic leukemia of B-cell origin: Oral manifestations and dental treatment planning (1997) J Am Dent Assoc, 128 (2), pp. 206-21