Chemical Study Of Sinningia Allagophylla Guided By Antiproliferative Activity Assays [estudo Químico De Sinningia Allagophylla Guiado Por Testes De Atividade Antiproliferativa]

Activity guided fractionation of Sinningia allagophylla (Mart.) Wiehler ethanolic extract yielded a new benzochromene 8-methoxylapachenol, besides seven known compounds: lapachenol, sitosteryl oleate, sitosteryl linoleate, stigmasteryl oleate, stigmasteryl linoleate, dunniol and tectoquinone. Extract, fractions, and compounds lapachenol, 8-methoxylapachenol, and dunniol were tested in vitro against human cancer cell lines U251 (glioma, CNS), MCF-7 (breast), NCI-ADR/RES (drug-resistant ovarian), 786-0 (kidney), NCI-H460 (lung, no small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon), K562 (leukemia) and against VERO, a normal cell line. The most active compound was dunniol, which inhibited the growth of U251, MCF-7, NCI-ADR/RES, OVCAR-3 and K562 cell lines.355974977Chautems, A., Lopes, T.C.C., Peixoto, M., Rossini, J., (2010) Candollea, 65, p. 241Araujo, A.O., Souza, V.C., Chautems, A., (2005) Rev. Bras. Bot., 28, p. 109Gomes, M.A.N., Shepherd, S.L.K., (2000) Rev. Bras. Bot., 23, p. 153Mors, W., Rizzini, C., Pereira, N., (2000) Medicinal Plants of Brazil, , Reference Publications Inc.: AlgonacStefanello, M.E.A., Cervi, A.C., Wisniewski Jr., A., (2005) Rev. Bras. Farmacogn., 15, p. 331Verdan, M., Barison, A., Sá, E., Salvador, M., Poliquesi, C., Eberlin, M., Stefanello, A.M.E., (2010) J. Nat. Prod., 73, p. 1434Jensen, S.R., (1996) Phytochemistry, 43, p. 777Swinny, E., Bloor, S., Wong, H., (2000) Magn. Reson. Chem., 38, p. 1031Winefield, C., Lewis, D., Swinny, E., Zhang, H., Arathoon, H., Fischer, T., Halbwirth, H., Davies, K., (2005) Physiol. Plant., 124, p. 419Verdan, M.H., Cervi, A.C., Campos, F.R., Barison, A., Stefanello, M.E.A., (2009) Biochem. Syst. Ecol., 37, p. 40Perret, M., Chautems, A., Spichiger, R., Kite, G., Savolainen, V., (2003) Am. J. Bot., 90, p. 445Pan, L., Chai, H., Kinghorn, A.D., (2010) Phytochem. Lett., 3, p. 1Reibenspies, J.H., Williams, H.J., Ortiz, C., Scott, A.I., Suarez, M., Domingues, X.A., (1989) J. Crystallogr. Spectrosc. Res., 19, p. 597Chaves, M.H., Citó, A.M.G.L., Lopes, J.A.D., Costa, D.A., Oliveira, C.A., Costa, A.F., Brito-Júnior, F.E.M., (2010) Rev. Bras. Farmacogn., 20, p. 106Shimada, Y., Hirota, Y., Baba, T., Sugihara, A., Moriyama, S., Tominaga, Y., Terai, T., (1999) J. Am. Oil Chem. Soc., 76, p. 713Khambay, B.P.S., Batty, D., Cahill, M., Denholm, I., Mead-Briggs, M., Vinall, S., Niemeyer, H.M., Simmonds, M.S.J., (1999) J. Agric. Food Chem., 47, p. 770Moreira, R.Y.O., Arruda, M.S.P., Arruda, A.C., Santos, L.S., Muller, A.H., Guilhon, G.M.S.P., Santos, A.S., Terezo, E., (2006) Rev. Bras. Farmacogn., 15, p. 392Costa, S.M.O., Lemos, T.L.G., Pessoa, O.D.L., Pessoa, C., Montenegro, R.C., Braz-Filho, R., (2001) J. Nat. Prod., 64, p. 792Itoigawa, M., Ito, C., Tan, H.T.-W., Okuda, M., Tokuda, H., Nishino, H., Furukawa, H., (2001) Cancer Lett., 174, p. 135Morello, A., Pavani, M., Garbarino, J.A., Chamy, M.C., Frey, C., Mancilla, J., Guerrero, A., Ferreira, J., (1995) Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 112, p. 119Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Boyd, M., (1991) J. Natl. Cancer Inst., 83, p. 757Shoemaker, R.H., (2006) Nat. Rev. Cancer, 6, p. 81