Development, Production And Characterization Of Nanocrystals Of Poorly Soluble Drugs [desenvolvimento, Produção E Caracterização De Nanocristais De Fármacos Pouco Solúveis]

Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.35918481853Durán, N., Durán, M., Tasic, L., Marcato, P., (2010) Quim. Nova, 33, p. 151Merisko-Liversidge, E.M., Liversidge, G.G., (2008) Toxicol. Pathol., 36, p. 43Junghanns, J.U., Müller, R.H., (2008) Int. J. Nanomedicine, 3, p. 295Miao, X., Sun, C., Jiang, T., Zheng, L., Wang, T., Wang, S., (2011) J. Pharm. Sci., 14, p. 196Sun, W., Mao, S., Shi, Y., Li, L.C., Fang, L., (2011) J. Pharm. Sci., 100, p. 3365Sylvestre, J.P., Tang, M.C., Furtos, A., Leclair, G., Meunier, M., Leroux, J.C., (2011) J. Control. Release, 149, p. 273Deng, J., Huang, L., Liu, F., (2010) Int. J. Pharm., 390, p. 242Ning, X., Sun, J., Han, X., Wu, Y., Yan, Z., Han, J., He, Z., (2011) Drug Dev. Ind. Pharm., 37, p. 727Lou, H., Zhang, X., Gao, L., Feng, F., Wang, J., Wei, X., Yu, Z., Zhang, Q., (2009) Int. J. Pharm., 379, p. 181Sigfridsson, K., Lundqvist, A.J., Strimfors, M., (2009) Drug Dev. Ind. Pharm., 35, p. 1479Ganta, S., Paxton, J.W., Baguley, B.C., Garg, S., (2009) Int. J. Pharm., 367, p. 179Rabinow, B., Kipp, J., Papadopoulos, P., Wong, J., Glosson, J., Gass, J., Sun, C.S., Wood, K., (2007) Int. J. Pharm., 339, p. 251Rabinow, B., (2005) Discov. Med., 5, p. 74Marques, I., Lopes, C.M., Souto, E.B., (2009) Rev. Facul. Ciências da Saúde, 6, p. 60Müller, R. H.Becker, R.Kruss, B.Peters, K.U.P. 5858410, 1999Shegokar, R., Müller, R.H., (2011) Int. J. Pharm., 399, p. 129Müller, R.H., Gohla, S., Keck, C.M., (2011) Eur. J. Pharm. Biopharm., 78, p. 1Möschwitzer, J., Müller, R.H., (2004) International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, , Nürnberg, GermanyVerma, S., Lan, Y., Gokhale, R., Burgess, D.J., (2009) Int. J. Pharm., 377, p. 185Keck, C.M., Müller, R.H., (2006) Eur. J. Pharm. Biopharm., 62, p. 3Chen, H., Khemtong, C., Yang, X., Chang, X., Gao, J., (2010) Drug Discov. Today, 16, p. 354Gülsün, T., Gürsoy, R.N., Öner, L., (2009) J. Pharm. Sci., 34, p. 55Xia, D., Cui, F., Piao, H., Cun, D., Piao, H., Jiang, Y., Ouyang, M., Quan, P., (2010) Pharm. Res., 27, p. 1965Petersen R. D.PCT/EP2007/009943, 2006Gao, Y., Li, Z., Sun, M., Guo, C., Yu, A., Xi, Y., Cui, J., Zhai, G., (2011) Drug Deliv, 18, p. 131Lou, H., Gao, L., Wei, X., Zhang, Z., Zheng, D., Zhang, D., Zhang, X., Zhang, Q., (2011) Colloids Surf. B, 87, p. 319Sahoo, N.G., Kakran, M., Shaal, L.A., Li, L., Müller, R.H., Pal, M., Tan, L.P., (2011) J. Pharm. Sci., 100, p. 2379Benita, S., Levy, M.Y., (1993) J. Pharm. Sci., 82, p. 1069Müller, R.H., Jacobs, C., Kayser, O., (2003) Em DissoCubes-A Novel Formulation for Poorly Soluble and Poorly Bioavailable Drugs;, , Rathbone M. J.Hadgraft, J.Roberts M. S., eds.Marcel Dekker: New YorkKuo, F., Subramanian, B., Kotyla, T., Wilson, T.A., Yoganathan, S., Nicolosi, R.J., (2008) Int. J. Pharm., 363, p. 206Muchow, M., Maincent, P., Müller, R.H., (2008) Drug Dev. Ind. Pharm., 34, p. 1394Wang, Y., Liu, Z., Zhang, D., Gao, X., Zhang, X., Duan, C., Jia, L., Zhang, Q., (2011) Colloids Surf. B, 83, p. 189Müller, R. H.Krause, K.Mäder, K.WO/2001/003670, 2001Martins, S., Tho, I., Ferreira, D.C., Souto, E.B., Brandl, M., (2011) Drug Dev. Ind. Pharm., 37, p. 815Teeranachaideekul, V., Junyaprasert, V.B., Souto, E.B., Müller, R.H., (2008) Int. J. Pharm., 354, p. 227Sahoo, N.G., Kakran, M., Shaal, L.A., Li, L., Müller, R.H., Pal, M., Tan, L.P., (2011) J. Pharm. Sci., 100, p. 2379Buttle, I.Dissertation, Freie Universität, Berlin, 2004Kipp, J. E. W.Joseph, C. T.Doty, M. J.Rebbeck, C. L.U.P. 6869617, 2001Bawa, R., (2010) Eur. J. Nanomedicine, 3, p. 34Merisko-Liversidge, E., Liversidge, G.G., Cooper, E.R., (2003) Eur. J. Pharm. Sci., 18, p. 113Shegokar, R., Singh, K.K., Müller, R.H., (2011) Int. J. Pharm., 416, p. 461Al Shaal, L., Müller, R.H., Shegokar, R., (2010) Pharmazie, 65, p. 877Han, X., Ghoroi, C., To, D., Chen, Y., Dave, R., (2011) Int. J. Pharm., 415, p. 185Gu, C.H., Grant, D.J., (2001) J. Pharm. Sci., 90, p. 1277Wang, Y., Li, X., Wang, L., Xu, Y., Cheng, X., Wei, P., (2011) Int. J. Nanomedicine, 6, p. 1497Li, W., Yang, Y., Tian, Y., Xu, X., Chen, Y., Mu, L., Zhang, Y., Fang, L., (2011) Int. J. Pharm., 408, p. 15