Necrosis Of Gastric Mucosa Following Orthostatic Collapse In Rabbits

Twenty-five rabbits were submitted to orthostatic collapse, divided into 6 groups and sacrificed about 4, 24 and 48 hours, 8, 15 and 30 days following collapse; two animals died during collapse and another 72 hours later. Seven animals were used as controls. Necrotic changes involving small areas of the gastric mucosa in the fundic and body portions were seen in successive stages up to regeneration. Such changes were present in all animals submitted to collapse, except three with no lesion. The necrosis is related to a nutritive disturbance of the gastric mucosa, mainly anoxic in nature. Grossly, the necrotic areas were similar to the acute erosions of the gastric mucosa seen in man. © 1973 Springer-Verlag.358210511