Lamotrigine In Epilepsy Of Difficult Control In Children [lamotrigina Em Epilepsia De Dificil Controle Na Infancia]

We present the results of a prospective, add-on, open trial with lamotrigine in 30 pediatric patients (aged 1 year 4 months to 16 years 8 months - average 6.5 years) with refractory seizures. The mean follow-up period was 25.7 months. Patients were classified according to the major epileptic syndrome. The best results obtained were patients with symptomatic partial epilepsy and myoclonic-astatic epilepsy. Fifteen patients had at least 50% reduction in seizure frequency. Fourteen patients had side effects; 5 patients who were taking valproate simultaneously exhibited skin rash after lamotrigine. This drug was withdrawn in 4 children and 1 patient had a rash that subsided with valproate withdrawal. The other side effects were transient and disappeared spontaneously with lamotrigine dose reduction or with valproate withdrawal.2211111