This paper is concerned with long-range adaptive predictive control of the biological nitrogen removal process in a pre-denitrification activated sludge plant. A control-oriented identification procedure is used for modelling a multi-step ahead (long-range) predictor using a reduced model of the nitrate concentration at the plant anoxic zone, in the range required by the predictive controller. The optimal structure of the reduced model and its parameters are identified by an advanced regression orthogonal estimator, based on the Modified Gram-Schmidt algorithm. The proposed controller controls the internal nitrate recirculation flow in order to maintain a desired nitrate concentration set-point at the anoxic zone. Simulation results, using ...