Hepatic biochemical changes in rats submitted to a high-fat/high-energy diet
- Moura, Leandro Pereira de
- Dalia, Rodrigo Augusto
- Araújo, Michel Barbosa de
- Sponton, Amanda Christine da Silva
- Pauli, José Rodrigo
- Moura, Rodrigo Ferreira de
- Mello, Maria Alice Rostom de
DOIAbstract
OBJECTIVE: The present study analyzed the biochemical and hepatic changes in adult rats fed a high-fat diet for two months. METHODS: Twenty Wistar rats 90 days old were divided into two groups, a control group consisting of normal weight rats fed a commercial rat chow and a diet group consisting of normal weight rats submitted to a semi-purified high-fat, high-energy diet. The animals in control group were kept on a commercial Purina® chow and those in diet group on a high-fat/high-energy diet containing 35% fat, of which 31% were from animal source (39% saturated fat) and 4% were from vegetable source (soybean oil). After 60 days of this experimental diet, the following were assessed: body weight, insulin sensitivity, blood glucose, serum ...
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