The Holliday junction (HJ) is a key intermediate in homologous recombination. It can be formed both as a consequence of RecA/ Rad51-catalysed strand invasion reactions, and by the reversal of impeded replication forks. HJs constitute physical connections between two DNA duplexes and therefore they have to be removed to enable DNA segregation during cell division. Nucleases, DNA helicases and topoisomerases are variously employed in different strategies of HJ removal, which in turn can influence whether a crossover or non-crossover recombinant DNA molecule is generated. This review will focus on two main types of endonuclease, the HJ resolvases and the Mus81 nucleases, which process HJs and/or related intermediates (e.g. forks, D-loops and n...
Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair ...
Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair ...
Enzymatic activities that cleave Holliday junctions are required for the resolution of recombination...
The Holliday junction (HJ) is a key intermediate in homologous recombination. It can be formed both ...
Four-way DNA intermediates, called Holliday junctions (HJs), can form during meiotic and mitotic rec...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Homologous recombination is required for maintaining genomic integrity by functioning in high-fideli...
Homologous recombination is required for maintaining genomic integrity by functioning in high-fideli...
The Holliday junction is a key recombination intermedi-ate whose resolution generates crossovers. In...
Homologous recombination is required for maintaining genomic integrity by functioning in high-fideli...
The heterodimeric nuclease Mus81–Eme1 has been proposed to be a Holliday junction resolvase and has ...
In eukaryotic cells, topoisomerase III forms an evolutionarily conserved complex with a RecQ family ...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair ...
Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair ...
Enzymatic activities that cleave Holliday junctions are required for the resolution of recombination...
The Holliday junction (HJ) is a key intermediate in homologous recombination. It can be formed both ...
Four-way DNA intermediates, called Holliday junctions (HJs), can form during meiotic and mitotic rec...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Homologous recombination is required for maintaining genomic integrity by functioning in high-fideli...
Homologous recombination is required for maintaining genomic integrity by functioning in high-fideli...
The Holliday junction is a key recombination intermedi-ate whose resolution generates crossovers. In...
Homologous recombination is required for maintaining genomic integrity by functioning in high-fideli...
The heterodimeric nuclease Mus81–Eme1 has been proposed to be a Holliday junction resolvase and has ...
In eukaryotic cells, topoisomerase III forms an evolutionarily conserved complex with a RecQ family ...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and r...
Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair ...
Holliday junction (HJ) resolution is essential for chromosome segregation at meiosis and the repair ...
Enzymatic activities that cleave Holliday junctions are required for the resolution of recombination...