Add to ORKGTo further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes theorem, credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs. In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal. Very few SNPs in our cre...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
<div><p>The increasing quantity and quality of functional genomic information motivate the assessmen...
The increasing quantity and quality of functional genomic information motivate the assessment and in...
To further investigate susceptibility loci identified by genome-wide association studies, we genotyp...
To further investigate susceptibility loci identified by genome-wide association studies, we genotyp...
Genome-wide association studies (GWAS) use custom SNP arrays that provide ef- fective genetic covera...
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the ge...
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the ge...
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the ge...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
<div><p>The increasing quantity and quality of functional genomic information motivate the assessmen...
The increasing quantity and quality of functional genomic information motivate the assessment and in...
To further investigate susceptibility loci identified by genome-wide association studies, we genotyp...
To further investigate susceptibility loci identified by genome-wide association studies, we genotyp...
Genome-wide association studies (GWAS) use custom SNP arrays that provide ef- fective genetic covera...
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the ge...
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the ge...
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the ge...
Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated wit...
<div><p>The increasing quantity and quality of functional genomic information motivate the assessmen...
The increasing quantity and quality of functional genomic information motivate the assessment and in...