Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells.

  • Rorsman, P
Publication date
January 1982

Abstract

D-glucose reduces the outflow of manganese from pancreatic beta-cells in analogy to what has previously been reported for 45Ca. The decrease can be accounted for by an enhanced intracellular sequestration. The effect of D-glucose on manganese fluxes seems to be restricted to inhibition of the efflux; no stimulation of the influx being noted. The glucose-dependence of manganese uptake is hyperbolic with half maximal stimulation between 5 and 6 mM D-glucose

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