Add to ORKGA series of novel danshensu amide derivatives were synthesized, and the protective effects of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results showed that all the seven compounds could significantly increased cell viability compared with hypoxia group. Among these compounds, 3-(3,4-dimethoxyphenyl)-2-hydroxy-N-propylpropanamide (6) exhibited good activities, with cell viability reached 94.2 % compared to the normal. The novel danshensu amide derivatives, possessing an additional lipophilic alkyl chain showed a good lipophilicity.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Chinese herbal drugs have been proved to be effective agents in myocardial protectionby preventing i...
Mitochondria play a crucial role in the mechanisms of cell death during events of acute myocardial i...
Chinese herbal drugs have been proved to be effective agents in myocardial protection by preventing ...
A series of novel danshensu amide derivatives were synthesized, and the protective effects of all th...
Danshen (Radix Salviae miltiorrhizae) and ChuanXiong (Ligusticum wallichii) are two traditional herb...
Mitochondrial permeability transition pore (MPTP) opening is the main culprit of ischemic/reperfusio...
Introduction: The search for new compounds with antihypoxic and cardioprotective effects among 3-oxy...
Free Radic Biol Med 2001 Jul 1;31(1):31-7 Related Articles, Books, LinkOut New synthetic flavonoids...
We have previously reported that the danshensu-cysteine conjugate N-((R)-3-benzylthio-1-methoxy-1-ox...
Danshen can induce the angiogenesis in advanced ischemic heart disease while inhibiting the angiogen...
Traditional Chinese medicines (TCMs) have been used in the clinic for thousands of years. Their reli...
A series of novel oleanolic acid 3-O-β-d-glucuronopyranoside derivatives have been designed and synt...
The paper presents results of a study of antioxidant (in vitro) and anti-ischemic effect of a number...
The activation of ATP-sensitive potassium channels (KATP), play a key role in an endogenous "self-de...
Danshen-Gegen (DG) decoction, an herbal formulation comprising Radix Salvia Miltiorrhiza and Radix P...
Chinese herbal drugs have been proved to be effective agents in myocardial protectionby preventing i...
Mitochondria play a crucial role in the mechanisms of cell death during events of acute myocardial i...
Chinese herbal drugs have been proved to be effective agents in myocardial protection by preventing ...
A series of novel danshensu amide derivatives were synthesized, and the protective effects of all th...
Danshen (Radix Salviae miltiorrhizae) and ChuanXiong (Ligusticum wallichii) are two traditional herb...
Mitochondrial permeability transition pore (MPTP) opening is the main culprit of ischemic/reperfusio...
Introduction: The search for new compounds with antihypoxic and cardioprotective effects among 3-oxy...
Free Radic Biol Med 2001 Jul 1;31(1):31-7 Related Articles, Books, LinkOut New synthetic flavonoids...
We have previously reported that the danshensu-cysteine conjugate N-((R)-3-benzylthio-1-methoxy-1-ox...
Danshen can induce the angiogenesis in advanced ischemic heart disease while inhibiting the angiogen...
Traditional Chinese medicines (TCMs) have been used in the clinic for thousands of years. Their reli...
A series of novel oleanolic acid 3-O-β-d-glucuronopyranoside derivatives have been designed and synt...
The paper presents results of a study of antioxidant (in vitro) and anti-ischemic effect of a number...
The activation of ATP-sensitive potassium channels (KATP), play a key role in an endogenous "self-de...
Danshen-Gegen (DG) decoction, an herbal formulation comprising Radix Salvia Miltiorrhiza and Radix P...
Chinese herbal drugs have been proved to be effective agents in myocardial protectionby preventing i...
Mitochondria play a crucial role in the mechanisms of cell death during events of acute myocardial i...
Chinese herbal drugs have been proved to be effective agents in myocardial protection by preventing ...