Doxorubicin represents a valuable choice for different cancers, although the severe side effects occurring at the high effective dose limits its clinical use. In the present study, potential strategies to potentiate low-dose doxorubicin efficacy, including a metronomic schedule, characterized by a short and repeated exposure to the anticancer drug, and the combination with the natural chemosensitizing sesquiterpenes β-caryophyllene and β-caryophyllene oxide, were assessed in human hepatoma HepG2 cells. The involvement of P-glycoprotein (P-gp) in the HepG2- chemosensitization to doxorubicin was evaluated. Also, the direct interaction of caryophyllene sesquiterpenes with P-gp was characterized by molecular docking and dynamic simulation studi...
Intracellular concentration of doxorubicin in target cancer cells is a major determinant of therapeu...
The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (...
Exposure to cigarette smoke (CS) has been associated with an increased risk of fatal breast cancers ...
Standard chemotherapy scheduling requires the administration of maximum tolerated doses of anticance...
Cholangiocarcinoma and hepatocellular carcinoma are primary liver cancers, both representing a growi...
The natural sesquiterpenes β-caryophyllene (CRY) and β-caryophyllene oxide (CRYO) were evaluated for...
Cholangiocarcinoma (CCA) represents a particular type of liver cancer originating from the epithelia...
The present study is designed to find out if sesquiterpenes, α-humulene (HUM), valencene (VAL), β-ca...
Hepatocellular carcinoma (HCC) is the fifth most frequent malignant tumor, and the third leading cau...
Hepatocellular carcinoma (HCC) is an aggressive malignant tumor, often associated with multidrug res...
Multidrug resistance (MDR) occurs when cancer cells develop cross-resistance to structurally and fun...
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising str...
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising str...
Many natural compounds are able to control apoptotic signaling pathways particularly by modulating t...
Several ATP-binding cassette (ABC) proteins reduce intracellular concentrations of antitumor drugs a...
Intracellular concentration of doxorubicin in target cancer cells is a major determinant of therapeu...
The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (...
Exposure to cigarette smoke (CS) has been associated with an increased risk of fatal breast cancers ...
Standard chemotherapy scheduling requires the administration of maximum tolerated doses of anticance...
Cholangiocarcinoma and hepatocellular carcinoma are primary liver cancers, both representing a growi...
The natural sesquiterpenes β-caryophyllene (CRY) and β-caryophyllene oxide (CRYO) were evaluated for...
Cholangiocarcinoma (CCA) represents a particular type of liver cancer originating from the epithelia...
The present study is designed to find out if sesquiterpenes, α-humulene (HUM), valencene (VAL), β-ca...
Hepatocellular carcinoma (HCC) is the fifth most frequent malignant tumor, and the third leading cau...
Hepatocellular carcinoma (HCC) is an aggressive malignant tumor, often associated with multidrug res...
Multidrug resistance (MDR) occurs when cancer cells develop cross-resistance to structurally and fun...
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising str...
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising str...
Many natural compounds are able to control apoptotic signaling pathways particularly by modulating t...
Several ATP-binding cassette (ABC) proteins reduce intracellular concentrations of antitumor drugs a...
Intracellular concentration of doxorubicin in target cancer cells is a major determinant of therapeu...
The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (...
Exposure to cigarette smoke (CS) has been associated with an increased risk of fatal breast cancers ...