Stroke remains a leading cause of death and disability in the world with limited therapies available to restrict brain damage or improve functional recovery after cerebral ischaemia. A promising strategy currently under investigation is the promotion of brain‐derived neurotrophic factor (BDNF) signalling through tropomyosin‐related kinase B (TrkB) receptors, a pathway essential for neuronal survival and function. However, TrkB and BDNF‐signalling are impaired by excitotoxicity, a primary pathological process in stroke also associated with neurodegenerative diseases. Pathological imbalance of TrkB isoforms is critical in neurodegeneration and is caused by calpain processing of BDNF high affinity full‐length receptor (TrkB‐FL) and an inversio...
The Trk family of receptors play a wide variety of roles in physiological and disease processes in b...
Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular...
SummaryImbalances in neurotrophins or their high-affinity Trk receptors have long been reported in n...
Stroke remains a leading cause of death and disability in the world with limited therapies available...
Abstract Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent cause of de...
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival through activa...
© 2019 The Authors.Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent ...
The neurotrophins and the tyrosine kinase (Trk) B receptor may play a protective role in the pathoph...
Ischemic stroke is one of the main causes of death, disability, and dementia in the world. The mecha...
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins form cation c...
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzhe...
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzhe...
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzhe...
Brain derived neurotrophic factor (BDNF) promotes cell survival, proliferation, differentiation, and...
Brain derived neurotrophic factor (BDNF) promotes cell survival, proliferation, differentiation, and...
The Trk family of receptors play a wide variety of roles in physiological and disease processes in b...
Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular...
SummaryImbalances in neurotrophins or their high-affinity Trk receptors have long been reported in n...
Stroke remains a leading cause of death and disability in the world with limited therapies available...
Abstract Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent cause of de...
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival through activa...
© 2019 The Authors.Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent ...
The neurotrophins and the tyrosine kinase (Trk) B receptor may play a protective role in the pathoph...
Ischemic stroke is one of the main causes of death, disability, and dementia in the world. The mecha...
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins form cation c...
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzhe...
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzhe...
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzhe...
Brain derived neurotrophic factor (BDNF) promotes cell survival, proliferation, differentiation, and...
Brain derived neurotrophic factor (BDNF) promotes cell survival, proliferation, differentiation, and...
The Trk family of receptors play a wide variety of roles in physiological and disease processes in b...
Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular...
SummaryImbalances in neurotrophins or their high-affinity Trk receptors have long been reported in n...