Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role in suppressing immune activation and inflammation. β2 integrins are important adhesion and signaling molecules that are exclusively expressed on leukocytes. The four β2 integrins (CD11a, CD11b, CD11c, and CD11d paired with the β2 chain CD18) play important roles in regulating three key aspects of immune cell function: recruitment to sites of inflammation; cell–cell contact formation; and downstream effects on cellular signaling. Through these three processes, β2 integrins both contribute to and regulate immune responses. This review explores the pro- and anti-inflammatory effects of β2 integrins in monocytes, macrophages, and dendritic cells ...
Inflammation is a crucial response against invading pathogens, in which immune cells, including neut...
The function of the immune system depends on tissue-specific leukocyte recruitment and microenvironm...
Macrophage accumulation is a critical step during development of chronic inflammation, initiating pr...
Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role ...
Leukocyte adhesion is of pivotal functional importance. Without adequate adhesion, T lymphocytes and...
Leukocyte adhesion is of pivotal functional importance. Without adequate adhesion, T lymphocytes and...
Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role in the inn...
Neutrophil-macrophage interplay is a fine-tuning mechanism that regulates the innate immune response...
Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on ...
The cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregula...
Integrins are heterodimeric adhesion molecules that play an important role in cell-to-cell, as well ...
Integrins are heterodimeric adhesion molecules that play an important role in cell-to-cell, as well ...
Integrins are heterodimeric adhesion molecules that play an important role in cell-to-cell, as well ...
Integrin α(D)β(2) is the most recently identified member of the leukocyte, or β(2), subfamily of int...
Inflammation is a crucial response against invading pathogens, in which immune cells, including neut...
Inflammation is a crucial response against invading pathogens, in which immune cells, including neut...
The function of the immune system depends on tissue-specific leukocyte recruitment and microenvironm...
Macrophage accumulation is a critical step during development of chronic inflammation, initiating pr...
Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role ...
Leukocyte adhesion is of pivotal functional importance. Without adequate adhesion, T lymphocytes and...
Leukocyte adhesion is of pivotal functional importance. Without adequate adhesion, T lymphocytes and...
Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role in the inn...
Neutrophil-macrophage interplay is a fine-tuning mechanism that regulates the innate immune response...
Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on ...
The cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregula...
Integrins are heterodimeric adhesion molecules that play an important role in cell-to-cell, as well ...
Integrins are heterodimeric adhesion molecules that play an important role in cell-to-cell, as well ...
Integrins are heterodimeric adhesion molecules that play an important role in cell-to-cell, as well ...
Integrin α(D)β(2) is the most recently identified member of the leukocyte, or β(2), subfamily of int...
Inflammation is a crucial response against invading pathogens, in which immune cells, including neut...
Inflammation is a crucial response against invading pathogens, in which immune cells, including neut...
The function of the immune system depends on tissue-specific leukocyte recruitment and microenvironm...
Macrophage accumulation is a critical step during development of chronic inflammation, initiating pr...