Classification of HHV-6A and HHV-6B as distinct viruses
- Ablashi, Dharam
- Agut, Henri
- Alvarez-Lafuente, Roberto
- Clark, Duncan A.
- Dewhurst, Stephen
- DiLuca, Dario
- Flamand, Louis
- Frenkel, Niza
- Gallo, Robert
- Gompels, Ursula A.
- Höllsberg, Per
- Jacobson, Steven
- Luppi, Mario
- Lusso, Paolo
- Malnati, Mauro
- Medveczky, Peter
- Mori, Yasuko
- Pellett, Philip E.
- Pritchett, Joshua C.
- Yamanishi, Koichi
- Yoshikawa, Tetsushi
DOIAbstract
Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in ...
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