Myasthenia gravis, the Lambert-Eaton myasthenic syndrome, and acquired neuromyotonia are three disorders of the neuromuscular junction or motor nerve that are caused by autoantibodies to ion channel proteins: acetylcholine receptors, voltage-gated calcium channels and voltage-gated potassium channels, respectively. The antibody titres can be measured using the relevant 125I-neurotoxins to label the extracted channels. Other disorders of the peripheral motor nerve are associated with antibodies to gangliosides. Sera with raised levels of anti-ganglioside antibodies have direct effects on the function of the distal motor nerve and motor nerve terminal. These conditions can be improved by therapies designed to reduce circulating antibodies. An...
The neuromuscular junction is the target of a variety of autoimmune, neurotoxic and genetic disorder...
Myasthenia gravis (MG) is one of the best understood autoantibody-mediated disorders. The pathogenic...
Acquired myasthenic syndromes are mostly autoimmune diseases with antibodies directed to ion channel...
Autoimmune disorders of the neuromuscular junction remain a paradigm for our understanding of autoim...
Autoantibodies directed against voltage- or ligand-gated ion channels and their associated proteins ...
Autoantibodies to acetylcholine receptors and to voltage-gated calcium and potassium channels are th...
BACKGROUND: The role of antibodies in neuromuscular junction disorders is well established with anti...
The neuromuscular junction represents a synapse between the motor nerve terminal and the surface of ...
It is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field o...
Antibodies to different membrane proteins, namely acetylcholine receptor, muscle specific kinase and...
The neuromuscular junction (NMJ) is a specialized synapse with a complex structural and functional o...
The neuromuscular junction (NMJ) is a prototype synapse and myasthenia gravis is the prototypic anti...
Autoimmunity has been demonstrated in a diverse range of peripheral neurological disorders, such as ...
The neuromuscular junction (NMJ) is a specialized synapse with a complex structural and functional o...
Antibodies are able to target and eliminate foreign pathogens such as viruses and bacteria. However,...
The neuromuscular junction is the target of a variety of autoimmune, neurotoxic and genetic disorder...
Myasthenia gravis (MG) is one of the best understood autoantibody-mediated disorders. The pathogenic...
Acquired myasthenic syndromes are mostly autoimmune diseases with antibodies directed to ion channel...
Autoimmune disorders of the neuromuscular junction remain a paradigm for our understanding of autoim...
Autoantibodies directed against voltage- or ligand-gated ion channels and their associated proteins ...
Autoantibodies to acetylcholine receptors and to voltage-gated calcium and potassium channels are th...
BACKGROUND: The role of antibodies in neuromuscular junction disorders is well established with anti...
The neuromuscular junction represents a synapse between the motor nerve terminal and the surface of ...
It is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field o...
Antibodies to different membrane proteins, namely acetylcholine receptor, muscle specific kinase and...
The neuromuscular junction (NMJ) is a specialized synapse with a complex structural and functional o...
The neuromuscular junction (NMJ) is a prototype synapse and myasthenia gravis is the prototypic anti...
Autoimmunity has been demonstrated in a diverse range of peripheral neurological disorders, such as ...
The neuromuscular junction (NMJ) is a specialized synapse with a complex structural and functional o...
Antibodies are able to target and eliminate foreign pathogens such as viruses and bacteria. However,...
The neuromuscular junction is the target of a variety of autoimmune, neurotoxic and genetic disorder...
Myasthenia gravis (MG) is one of the best understood autoantibody-mediated disorders. The pathogenic...
Acquired myasthenic syndromes are mostly autoimmune diseases with antibodies directed to ion channel...