Resistin, acute coronary syndrome and prognosis results from the Athero<i>Gene</i> study

&lt;p&gt;&lt;b&gt;Objective&lt;/b&gt; &lt;br&gt;Resistin, an adipocyte and macrophage derived cytokine, causes insulin resistance and glucose intolerance. We investigated the impact of resistin as a diagnostic marker in patients with acute coronary syndrome and its prognostic value for future cardiovascular events.&lt;/br&gt;&lt;/p&gt; &lt;p&gt;&lt;b&gt;Methods&lt;/b&gt; &lt;br&gt;Resistin levels were determined in 1153 patients with stable angina (SAP), 380 patients with unstable angina, 278 patients with non-ST-elevation myocardial infarction (NSTEMI) and 111 patients with ST-elevation myocardial infarction (STEMI). All patients have been followed up for a median follow-up of 2.6 years. During follow-up, 70 patients died from cardiovascular causes.&lt;/br&gt;&lt;/p&gt; &lt;p&gt;&lt;b&gt;Results&lt;/b&gt; &lt;br&gt;Compared to SAP, resistin levels (5.1 ng/mL in SAP) were elevated in patients with angina at rest (5.89 ng/mL, P = 0.001), in patients with NSTEMI (6.00 ng/mL, P &#x3C; 0.001), and in patients with STEMI (5.98 ng/mL, P &#x3C; 0.001). Resistin levels rose at 3–6 h after chest pain onset (5.46 ng/mL), persisted elevated among those individuals presenting between 6 and 12 h after chest pain onset (5.57 ng/mL) and peaked in individuals presenting more than 12 h after chest pain onset (5.74 ng/mL). An increase of one standard deviation of resistin levels was associated with a 1.22-fold (95% CI 1.04–1.43; P = 0.02) risk for future fatal cardiovascular events in a model adjusted for risk factors and clinical and therapeutic variables. When adjustment for renal function was applied, this association lost its statistical significance.&lt;/br&gt;&lt;/p&gt; &lt;p&gt;&lt;b&gt;Conclusions&lt;/b&gt; &lt;br&gt;Resistin levels are elevated in patients presenting with unstable angina, NSTEMI and STEMI and might play a role as a diagnostic marker. In addition, systemic resistin level is moderately associated with future cardiovascular death in patients with documented coronary artery disease.&lt;/br&gt;&lt;/p&gt