Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

Reid, Caroline M.
Ebikeme, Charles
Barrett, M.P.
Patzewitz, Eva-Maria
Muller, S.
Robins, David J.
Sutherland, Andrew

Publication date

January 2008

DOI

10.1016/j.bmcl.2008.09.047

Abstract

Efficient synthetic routes have been developed for the preparation of two new polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 aminopurine transporter. Biological testing of these compounds showed highly selective anti-protozoal activity against trypanosome

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Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

Abstract

Extracted data

Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

Abstract

Extracted data

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